Custom LNA GapmeRs and siRNAs for your targets of interest
Create and order with our user-friendly online design tools
RNA SILENCER DESIGNERS
Specific and effective knock-down in RNA silencing experiments
Choose from our versatile range of customized RNA silencing tools to meet your experimental needs with unmatched precision and efficiency. Our selection includes:
- Antisense LNA GapmeRs: These antisense oligonucleotides operate independently of the RNA-induced silencing complex (RISC), significantly reducing miRNA-like, off-target effects. They are also an ideal choice for accurate and strand-specific silencing of lncRNA targets.
- siRNAs: Our siRNA offerings support a broad spectrum of analyses. Whether you need tubes or plates of siRNAs for cost-effective screening or high-purity, custom siRNAs equipped with various fluorescent labels, we have you covered.
Products | Antisense LNA GapmeRsFor highly effective knockdown of mRNA and lncRNA using LNA-enhanced antisense oligonucleotides | HP Custom siRNAFor efficient gene silencing using high-purity siRNA | Custom FlexiPlate siRNAFor highly flexible and economical RNAi screening |
|---|---|---|---|
| Applications | Silencing of lncRNA and mRNA in cell cultures and in animal models | Silencing of genes for a variety of applications | Pathway analysis, follow-up screening experiments |
| Target | mRNA or lncRNA sequences >80 nucleotides | Customer-input target sequence | Human, mouse and rat genes |
| Species | Human, mouse, rat (others available through QIAGEN technical support) | Specific splice variants of multiple species including non-human, -mouse, and -rat | Human, mouse and rat |
| Synthesis Scale | 5 nmol, 15 nmol, others | 20 nmol | 0.1 nmol, 0.25 nmol, 1 nmol |
| Grades | Standard, premium, in vivo-ready, in vivo large-scale | High-Performance–Purity (HPP) grade | Suitable for flexible, economical RNAi screening or screening follow-up |
| Format | Varies | Lyophilized in tubes or 96-well plates | 96- and 384-well plates |
| Oligo Type | LNA-enhanced | Standard oligonucleotide | Standard oligonucleotide |
| Labels | Varies | 3' or 5' end of sense strand: Alexa Fluor 488, Alexa Fluor 546, Alexa Fluor 555, Alexa Fluor 647, Cyanine 570, Cyanine 670, fluorescein, rhodamine | None |