TR/RXR Activation
Thyroid hormone affects a range of biological processes such as growth, development and metabolism. The biologically active form of the hormone is triiodothyronine (T3); it acts through nuclear receptors TR (thyroid receptor) alpha and beta. TR is usually found as a heterodimer with RXR. Binding of T3 to TR releases the repressor complex from the TR-RXR heterodimer. T3 bound TR-RXR along with a number of co-activators can then regulate gene expression...
Pathway Summary
Thyroid hormone affects a range of biological processes such as growth, development and metabolism. The biologically active form of the hormone is triiodothyronine (T3); it acts through nuclear receptors TR (thyroid receptor) alpha and beta. TR is usually found as a heterodimer with RXR. Binding of T3 to TR releases the repressor complex from the TR-RXR heterodimer. T3 bound TR-RXR along with a number of co-activators can then regulate gene expression. TR is also involved in a non-genomic action through activation of PI3K pathway. Perturbation of thyroid hormone and its receptors affects various processes including lipid metabolism, carbohydrate metabolism, steroid metabolism, thermogenesis and CNS function.
TR/RXR Activation Genes list
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ACACAacetyl-CoA carboxylase alpha ADRB1adrenoceptor beta 1 AKR1C1aldo-keto reductase family 1 member C1 AKR1C2aldo-keto reductase family 1 member C2 AKR1C3aldo-keto reductase family 1 member C3 AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 APOA5apolipoprotein A5 ATP2A1ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 BCL3BCL3 transcription coactivator CAMK4calcium/calmodulin dependent protein kinase IV CAMPcathelicidin antimicrobial peptide COL6A3collagen type VI alpha 3 chain CYP7A1cytochrome P450 family 7 subfamily A member 1 DIO1iodothyronine deiodinase 1 DIO2iodothyronine deiodinase 2 DIO3iodothyronine deiodinase 3 ENO1enolase 1 EP300E1A binding protein p300 F10coagulation factor X FASNfatty acid synthase FGAfibrinogen alpha chain G6PC1glucose-6-phosphatase catalytic subunit 1 GH1growth hormone 1 GPS2G protein pathway suppressor 2 HDAC3histone deacetylase 3 HIF1Ahypoxia inducible factor 1 subunit alpha HPhaptoglobin KLF9Kruppel like factor 9 LDLRlow density lipoprotein receptor MDM2MDM2 proto-oncogene ME1malic enzyme 1 MED1mediator complex subunit 1 MTORmechanistic target of rapamycin kinase NCOA1nuclear receptor coactivator 1 NCOA2nuclear receptor coactivator 2 NCOA3nuclear receptor coactivator 3 NCOA4nuclear receptor coactivator 4 NCOA6nuclear receptor coactivator 6 NCOR1nuclear receptor corepressor 1 NCOR2nuclear receptor corepressor 2 NRGNneurogranin NXPH2neurexophilin 2 PCK1phosphoenolpyruvate carboxykinase 1 PDE3Bphosphodiesterase 3B PFKPphosphofructokinase, platelet PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PPARGC1APPARG coactivator 1 alpha RAB3BRAB3B, member RAS oncogene family RCAN2regulator of calcineurin 2 RXRAretinoid X receptor alpha RXRBretinoid X receptor beta RXRGretinoid X receptor gamma SCARB1scavenger receptor class B member 1 SLC16A2solute carrier family 16 member 2 SLC16A3solute carrier family 16 member 3 SLC2A1solute carrier family 2 member 1 SREBF1sterol regulatory element binding transcription factor 1 SREBF2sterol regulatory element binding transcription factor 2 STRBPspermatid perinuclear RNA binding protein SYT12synaptotagmin 12 SYT2synaptotagmin 2 TBL1XR1TBL1X receptor 1 TBL1Ytransducin beta like 1 Y-linked THRAthyroid hormone receptor alpha THRBthyroid hormone receptor beta THRSPthyroid hormone responsive TRHthyrotropin releasing hormone TSHBthyroid stimulating hormone subunit beta UCP1uncoupling protein 1 UCP2uncoupling protein 2 UCP3uncoupling protein 3
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