VDR/RXR Activation
1alpha,25-dihydroxyvitamin D3 (vitamin D3) is a hormone that plays a crucial role in the regulation/metabolism of calcium and phosphorus in the small intestine, kidney and bone. In addition it is also involved in immune function, tumor suppression, growth regulation and parathyroid hormone secretion. VDR, the vitamin D3 receptor, exists as a heterodimer with RXR. Vitamin D3-bound VDR-RXR, along with other co-activator proteins, mediates the transcriptional regulation of a number of genes. Hence any disruption to the vitamin or its receptor would have consequences in a number of the key physiological processes listed above...
Pathway Summary
1alpha,25-dihydroxyvitamin D3 (vitamin D3) is a hormone that plays a crucial role in the regulation/metabolism of calcium and phosphorus in the small intestine, kidney and bone. In addition it is also involved in immune function, tumor suppression, growth regulation and parathyroid hormone secretion. VDR, the vitamin D3 receptor, exists as a heterodimer with RXR. Vitamin D3-bound VDR-RXR, along with other co-activator proteins, mediates the transcriptional regulation of a number of genes. Hence any disruption to the vitamin or its receptor would have consequences in a number of the key physiological processes listed above.
VDR/RXR Activation Genes list
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BGLAPbone gamma-carboxyglutamate protein CALB1calbindin 1 CAMPcathelicidin antimicrobial peptide CASRcalcium sensing receptor CCL5C-C motif chemokine ligand 5 CCNCcyclin C CD14CD14 molecule CDKN1Acyclin dependent kinase inhibitor 1A CDKN1Bcyclin dependent kinase inhibitor 1B CEBPACCAAT enhancer binding protein alpha CEBPBCCAAT enhancer binding protein beta COL13A1collagen type XIII alpha 1 chain CSF2colony stimulating factor 2 CSNK2A1casein kinase 2 alpha 1 CST6cystatin E/M CXCL10C-X-C motif chemokine ligand 10 CYP24A1cytochrome P450 family 24 subfamily A member 1 CYP27B1cytochrome P450 family 27 subfamily B member 1 EP300E1A binding protein p300 FOXO1forkhead box O1 GADD45Agrowth arrest and DNA damage inducible alpha GTF2Bgeneral transcription factor IIB HES1hes family bHLH transcription factor 1 HOXA10homeobox A10 HRHR lysine demethylase and nuclear receptor corepressor HSD17B2hydroxysteroid 17-beta dehydrogenase 2 IFNGinterferon gamma IGFBP1insulin like growth factor binding protein 1 IGFBP3insulin like growth factor binding protein 3 IGFBP5insulin like growth factor binding protein 5 IGFBP6insulin like growth factor binding protein 6 IL12Ainterleukin 12A IL1RL1interleukin 1 receptor like 1 IL2interleukin 2 KLF4Kruppel like factor 4 KLK6kallikrein related peptidase 6 LRP5LDL receptor related protein 5 MED1mediator complex subunit 1 MXD1MAX dimerization protein 1 NCOA1nuclear receptor coactivator 1 NCOA2nuclear receptor coactivator 2 NCOA3nuclear receptor coactivator 3 NCOR1nuclear receptor corepressor 1 NCOR2nuclear receptor corepressor 2 PDGFAplatelet derived growth factor subunit A PPARDperoxisome proliferator activated receptor delta PRKCAprotein kinase C alpha PRKCBprotein kinase C beta PRKCDprotein kinase C delta PRKCEprotein kinase C epsilon PRKCGprotein kinase C gamma PRKCHprotein kinase C eta PRKCIprotein kinase C iota PRKCQprotein kinase C theta PRKCZprotein kinase C zeta PRKD1protein kinase D1 PRKD3protein kinase D3 PSMC5proteasome 26S subunit, ATPase 5 PTHparathyroid hormone RUNX2RUNX family transcription factor 2 RXRAretinoid X receptor alpha RXRBretinoid X receptor beta RXRGretinoid X receptor gamma S100GS100 calcium binding protein G SEMA3Bsemaphorin 3B SERPINB1serpin family B member 1 SP1Sp1 transcription factor SPP1secreted phosphoprotein 1 SULT2A1sulfotransferase family 2A member 1 TGFB2transforming growth factor beta 2 THBDthrombomodulin TNFSF11TNF superfamily member 11 TRPV5transient receptor potential cation channel subfamily V member 5 TRPV6transient receptor potential cation channel subfamily V member 6 VDRvitamin D receptor WT1WT1 transcription factor YY1YY1 transcription factor
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