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GeneGlobe ID: JHS-3001Z | Cat. No.: | QIAseq RNA Fusion XP Panels

RNA Fusion XP Oncology Research Panel

Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq

Select a variant to see the price

Product Specification

Target List

Bone Cancer
Askins Tumors​
ERGEWSR1FLI1FUS
Ewing's Sarcomas​
ERGETV1ETV4EWSR1FEVFLI1FUSNFATC2SMARCA5
Giant Cell Tumors​
EWSR1FLI1
Mesenchymal Chondrosarcomas​
CDX1HEY1IRF2BP2NCOA2
Myxoid Chondrosarcomas​
EWSR1NR4A3 (NOR1)TAF15TCF12TFG
Brain Cancer
Gliomas​
AKT2BRAFCLCN6FAM131BFGFR1FGFR3FIP1L1GNAI1GOPCMKRN1MYBPDGFRAPRKCBRAF1RNF130ROS1SRGAP3TACC1TACC3
Neuroblastomas​
EWSR1FLI1
Pilocytic Astrocytomas​
CLCN6FAM131BGNAI1MKRN1RNF130SRGAP3TACC1
Other Brain Cancers​
EWSR1FLI1NAB2PDGFRAPRKCASTAT6
Breast Cancer
Carcinomas​
AKT2BRD3DAZLETV6FGFR1JAK1KIT (CD117)MAST1MAST2NTRK3PIK3CA (p110-alpha)RAF1TBL1XR1ZC3H7BZNF703
Ductal Carcinomas​
DAZLETV6NTRK3
Other Breast Cancers​
AKT3ESR1 (ERα)NOTCH2
Colorectal Cancer
Adenocarcinomas​
ETV6INSRNTRK1NTRK3TCF7L2TPM3VTI1A
Kidney Cancer
Carcinomas​
ALKASPSCR1PRCCTFE3VCL
Clear Cell Sarcomas​
TERT
Mesoblastic Nephromas​
ETV6NTRK3
Renal Cell Carcinomas​
TFEBVCL
Leukemia
Acute Leukemia of Ambiguous Lineage​
ABL1AFF1BCRCT45A2ETV6EWSR1GPHNKMT2AMLLT10MN1NUP214PBX1SETTCF3ZNF384
Acute Lymphoblastic Leukemia (ALL)​
ABL1ABL2 (ARG)ACTN4AFDNAFF1AFF3AFF4AGGF1ANLNASNSATF7IPAUTS2BCL11BBCL9BCRBTBD18CASC5CREBBP (CBP)CRLF2 (TSLPR)CSF1RDDX3XEBF1ELLELNEML1EP300EPOREPS15ESRRBETV6EWSR1FGFR1FGFR1OPFLT3FOXO4FOXP1FRYLGAS7GPHNHLFHNRNPUL1IL2RBINPP5DJAK2KMT2AKMT2ELNP1MAML2MEF2DMLLT1MLLT10MLLT3MN1MNX1MYBMYCNCOA2NOTCH1NUP214NUP98P2RY8PAG1PAX5PBX1PCM1PDGFRBPICALMPMLPRDM16RAP1GDS1RARARCSD1RUNX1 (AML1)SALL2SETSFPQSPI1SSBP2STILSTMN1TAF15TAL1TCF3TCF7TET1TSLPTYK2USP9XZBTB16ZCCHC7ZMIZ1ZMYM2ZNF384ZNF521
Acute Myeloid Leukemia (AML)​
ABI1ABI2ABL1AFDNAFF1AFF4ALKANLNARHGAP26ARHGEF12BCORBCRCASC5CBFA2T3CBFBCBLCCDC88CCEP170BCHD1CHIC2CREBBP (CBP)DAB2IPDDX10DEKDHHDIAPH2ELLEP300EPS15ERGETV6FGFR1FIP1L1FLNAFNBP1FOXO3FOXO4FRYLFUSGAS7GATA1GLIS2GPHNHAUS1HOXA9HOXC11HOXC13HOXD13IRF2BP2JAK2KAT6AKDM5AKIAA1524KIT (CD117)KMT2ALASP1LNP1LPPLYNMAML2MECOMMKL1MLF1MLLT1MLLT10MLLT11MLLT3MLLT6MN1MNX1MYBMYH11MYO1FNCKIPSDNCOA2NF1NPM1NSD1NTRK3NUMA1NUP214NUP98PAN3PBX1PCM1PDGFRAPDGFRBPDS5APHF23PICALMPMLPRDM16PRRX1PSIP1PSMA2PTPRRRANBP2RARARBM15RHEBL1RPL22RPN1RUNX1 (AML1)RUNX1T1SARNPSEPT2SEPT5SEPT6SEPT9SETSH3GL1SORBS2STAT5BTAF15TCF3TET1TFGTOP1TOP3ATRIP11TYK2UBA2USP42WHSC1L1WTIPZBTB16ZFYVE19ZNF384
Acute Myelomonocytic Leukemia (AMML)​
FLNAHOXD13NUP98
B-Cell Acute Lymphoblastic Leukemia (B-ALL)​
ABL1ACTN4AFF1AFF3AFF4ATF7IPBCRBTBD18CRLF2 (TSLPR)EPS15ERGESRRBETV6EWSR1FUSGAS7JAK2KMT2AMAPRE1MLLT1NUP214P2RY8PAX5PBX1PCM1RUNX1 (AML1)SETSSBP2TCF3USP9XZNF384ZNF521
Blast Phase Chronic Myeloid Leukemia​
ABL1BCRETV6JAK2
Chronic Eosinophilic Leukemia​
ACSL6TNIP1
Chronic Lymphocytic Leukemia (CLL)​
MYCNOTCH1
Chronic Myeloid Leukemia (CML)​
ABL1BCRCCDC88CETV6HOXA11HOXA13JAK2MECOMMN1NDE1NUP98PCM1PDGFRBRUNX1 (AML1)
Chronic Myelomonocytic Leukemia (CMML)​
CREBBP (CBP)ELLETV6KMT2AMN1
Myelodysplastic Syndromes (MDS)​
ABL1ACTN4ALKCASC5CREBBP (CBP)DEKERGETV6FRYLFUSHOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1NDE1NPM1NUP214NUP98PCM1PDGFRBPRDM16PTPRRRANBP2RUNX1 (AML1)RUNX1T1TOP1
Myeloproliferative Neoplasms​
ABL1ACSL6BCRETV6FGFR1FGFR1OPFIP1L1FLT3HOXA9HOXD13JAK2LYNMECOMMLF1MN1NPM1NUP98PDGFRBPRKG2PSIP1RARARUNX1 (AML1)TNIP1ZMYM2
T-Cell Acute Lymphoblastic Leukemia (T-ALL)​
ABL1AFDNAGGF1ASNSBCL11BBCRCASC5DDX3XETV6JAK2KMT2AKMT2EMLLT1MLLT10NOTCH1NUP214PBX1RUNX1 (AML1)SALL2SETSPI1STILSTMN1TAL1TCF3TCF7
Other Leukemias​
BCL11BIKZF2IKZF3IRF2BP2MYCNPM1PDCD1LG2SETD2TYK2
Liver Cancer
Cholangiocarcinomas​
CCDC6FGFR2TACC3
Hepatocellular Carcinomas​
PKN1
Lung Cancer
Acinar Adenocarcinomas​
ALKCD74EML4HIP1KIF5BROS1SDC4
Adenocarcinomas​
ALKBAIAP2L1BCL11ABRAFCCDC6CD74CUX1EML4ERBB2 (HER-2, NEU)ERBB4EZRFGFR2FGFR3GCC2GOPCHIP1HLA-DRB1KIAA1217KIF5BKLC1LRIG3METMPRIPNCOA4NRG1 (HGL)NTRK1NTRK2PBX1PRKCBRETROS1SDC4SLC34A2SND1STARD3NLSTRNTACC3TCF3TFGTPM3TPRTRIM24TRIM33
Bronchioloalveolar Adenocarcinomas​
ALKEML4KLC1PBX1ROS1SDC4TCF3
Inflammatory Myofibroblastic Tumors​
ALKCD74EML4EZRGOPCLRIG3PPFIBP1ROS1SDC4SLC34A2TPM3
Invasive Mucinous Adenocarcinomas​
ALKCD74EML4NRG1 (HGL)SLC3A2
Mixed Adenosquamous Carcinomas​
ALKEML4KIF5BRET
Mucoepidermoid Carcinomas​
ALKCRTC1EML4MAML2
Non-Small Cell Carcinomas​
ALKBCL11ACCDC6CD74CUX1EGFR (ERBB1)EML4EZRGCC2GOPCHIP1KIAA1217KIF5BKLC1LRIG3NCOA4RETROS1SDC4SLC34A2STRNTFGTPM3TPRTRIM33
Non-Small Cell Lung Cancers (NSCLC)​
ALKBAG4BAIAP2L1BCL11ACCDC6CD74CLIP4CUX1DNAH5EGFR (ERBB1)EML4ETV6EZRFERFGFR1FGFR3GCC2GLRX5GOPCHIP1HLA-DRB1IRF2BP2KIAA1217KIF5BKLC1LRIG3MAN2A1METMPRIPNCOA4NRG1 (HGL)NTRK1NTRK3RAD51RETROS1RUNX1 (AML1)SDC4SLC34A2SLC3A2SQSTM1STRNTACC3TFGTPM3TPRTRA2BTRIM33VSNL1
Squamous Cell Carcinomas (SCC)​
ALKBAIAP2L1CD74EML4FGFR2FGFR3FGRHIP1KIF5BKIT (CD117)NRG1 (HGL)PKN1PRKCAPRKCBRETTACC3
Other Carcinomas​
ALKBRD4EML4NUTM1
Other Lung Cancers​
ARL17ABAG4BAIAP2L1CCDC6CD74CUX1EZRFGFR1FGFR3GOPCIRF2BP2KANSL1KIAA1217KIF5BLRIG3MPRIPNCOA4NRG1 (HGL)NTRK1NUTM1PTPRKRETROS1RSPO3SDC4SLC34A2SLC3A2SQSTM1TACC3TPM3TPRTRIM33WHSC1L1
Lymphoma
Acute Lymphoblastic Lymphomas​
BCL11BCREBBP (CBP)EBF1KMT2AMLLT10MYCP2RY8PRDM16STIL
Anaplastic Large Cell Lymphomas​
ADGRG7ALKATICCLTCMSNMYCNPM1TFGTPM3TPM4
Angioimmunoblastic T Cell Lymphomas​
CD28CTLA4FIP1L1PDGFRA
Burkitt Lymphomas​
BCL6MYCPBX1TCF3
Diffuse Large B Cell Lymphomas (DLBCL)​
ALKBCL11ABCL6CCND3CIITACLTCIGLL5LPPMAPK13 (p38delta)MYCNPM1PIM1RELSQSTM1TBL1XR1TOMM40TP63ZCCHC7
Follicular Lymphomas​
AFF3BCL2BCL6CIITAMYCTBL1XR1TP63
Granulocytic Sarcomas​
RUNX1 (AML1)RUNX1T1
Hodgkin Lymphomas​
ALKCIITAJAK2NPM1SEC31A
Inflammatory Myofibroblastic Tumors​
ALKCARSDCTN1
Lymphoblastic Lymphomas​
BCRCRLF2 (TSLPR)EPORETV6FGFR1NOTCH1PBX1PDGFRBRARATERTZCCHC7
Lymphoblastic T Cell Lymphomas​
BCRETV6FGFR1FIP1L1LYNPDGFRA
Mantle Cell Lymphomas​
CCND3MYC
Mediastinal Large B Cell Lymphomas (MLBL)​
CIITAPDCD1LG2
Mediastinal Large B-Cell Lymphomas​
CIITAPDCD1LG2
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas​
BCL6BIRC3 (c-IAP2)CCND3MALT1MYC
Peripheral T Cell Lymphomas​
ALKETV6FGFR3IKZF2ITKMYO1FNPM1S100A7SYKTBL1XR1THAP4TP63VAV1
Precursor T Cell Lymphoblastic Lymphomas​
ABL1JAK2NUP214PCM1SET
T Cell Lymphomas​
ATXN2LBCL11BFGFR1IKZF2JAK2
Other Lymphomas​
ALKATXN2LBCL6BIRC3 (c-IAP2)CBFBCCND1CCND3CDK6CHIC2CLTCDEKDUSP22EIF4A1JAK2KMT2AMALT1MKL1MLF1MLLT10MYCNFKB2NPM1PICALMPRDM16
Myelodysplastic Syndromes (MDS)
ABL1ACTN4ALKCASC5CREBBP (CBP)DEKDIAPH2ERGETV6FGFR1FRYLFUSGOT1HOXA11HOXA13HOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1MYH11NDE1NPM1NUP214NUP98PAN3PCM1PDGFRBPRDM16PSMA2PTPRRRANBP2RUNX1 (AML1)RUNX1T1SEPT9SYKTOP1ZMYM2
Myeloproliferative Neoplasms
ABL1ACSL6BCRCNTRLETV6FGFR1FGFR1OPFIP1L1FLT3FOXP1HOXA9HOXD13JAK2KANK1LYNMECOMMLF1MN1NPM1NUP98PCM1PDGFRAPDGFRBPRKG2PSIP1RARARUNX1 (AML1)TNIP1
Ovarian Cancer
Carcinomas​
ESRRA
Serous Cyst Adenocarcinomas​
AKT2AXLFGRINSRJAK1
Pancreatic Cancer
Acinar Cell Carcinomas​
GATMHACL1HERPUD1SND1ZSCAN30
Adenocarcinomas​
ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2 (hGK-1, hK2)KRASNDRG1PIK3CA (p110-alpha)RAF1SLC45A3TBL1XR1TMPRSS2UBE2L3
Carcinomas​
BRAFRAF1
Prostate Cancer
Adenocarcinomas​
ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2 (hGK-1, hK2)KRASNDRG1PIK3CA (p110-alpha)RAF1SLC45A3TBL1XR1TMPRSS2UBE2L3
Glandular Intraepithelial Neoplasia​
ERGTMPRSS2
Other Carcinomas​
ERGETV1TMPRSS2
Salivary Gland Cancer
Adenomas​
FGFR1PLAG1
Mucoepidermoid Carcinomas​
CRTC1MAML2
Warthin Tumors​
CRTC1MAML2
Other Carcinomas​
ETV6NTRK3
Other Salivary Gland Cancers​
MYB
Sarcoma
Alveolar Soft Part Sarcomas​
ASPSCR1TFE3
Angiosarcomas & Epitheliod Haemangioendotheliomas​
CAMTA1CEP85LCICLEUTXROS1TFE3YAP1
Askins Tumors​
ERGEWSR1FLI1FUS
Chondrosarcomas​
ACVR2ACDX1EWSR1FN1HEY1IRF2BP2NCOA2NR4A3 (NOR1)TAF15TCF12TFG
Clear Cell Sarcomas​
ATF1CREB1EWSR1FLI1NUTM2BYWHAE
Congenital (Infantile) Fibrosarcomas​
ETV6METNTRK3TFG
Dermatofibrosarcoma Protuberans​
COL1A1PDGFB
Dermatofibrosarcomas Protuberans​
COL1A1PDGFB
Desmoplastic Small Round Cell Tumors​
ERGEWSR1FLI1PATZ1WT1
Endometrial Stromal Sarcomas​
ALKBCORCXorf67EPC1FN1JAZF1MBTD1MEAF6NUTM2ANUTM2BPHF1SUZ12YWHAEZC3H7B
Epithelioid Sarcomas​
CREB3L1CREB3L2EWSR1FUSKLF17SS18SSX1
Ewing's Sarcomas​
CICERGETV1ETV4EWSR1FEVFLI1FOXO4FUSNFATC2SMARCA5SP3
Fibrosarcomas​
BRAFCOL1A1CREB3L1CREB3L2EWSR1FUSLMNANTRK1PDGFBTOM1L2
Leiomyosarcomas​
EWSR1HMGA2PBX3WT1
Liposarcomas​
DDIT3 (GADD153, CHOP)EWSR1FUSHMGA2LGR5NUP107TERT
Myofibroblastic Sarcomas​
ALKLMNANTRK1RELAROS1SRFTFGTPM3YWHAE
Myxofibrosarcomas​
CREB3L1CREB3L2FUS
Myxoid Chondrosarcomas​
NR4A3 (NOR1)TAF15
Perivascular Epithelioid Cell Tumors (PEComa)​
DVL2SFPQTFE3
Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)​
CITED2MED12PRDM10
Rhabdoid Tumors​
NCOA4RET
Rhabdomyosarcomas​
CITED2EWSR1FLI1FOXO1NCOA1NCOA2PAX3PAX7SRFTEAD1VGLL2
Small Round Cell Tumors​
ERGETV1EWSR1FEVFLI1FOXO1PAX3
Solitary Fibrous Tumors​
NAB2STAT6
Synovial Sarcomas​
COL6A3CSF1 (MCSF)S100A10SS18SS18L1SSX1SSX2SSX2BSSX4B
Undifferentiated; Unclassified or Other Sarcomas​
ATF1BCORBRD4CCNB3CREMERGETV4EWSR1FGF1FGFR1FLI1FN1FOXO1FUSGLI1JAZF1MAML3MKL2NPM1NUTM1PAX3PLAG1POU5F1 (OCT4)RUNX1 (AML1)RUNX1T1SUZ12USP6
Skin Cancer
Adnexal Tumors; Hidradenomas​
CRTC1MAML2
Atypical Spitzoid Tumors​
ALKTPM3
Benign Melanocytic Nevus​
ALKBRAFCEP89ERC1FCHSD1GOLGA5KIF5BLSM14AMYO5APPFIBP1PWWP2ARETROS1TPM3
Melanomas​
AGKATF1BRAFCREB1EWSR1FCHSD1FGRPAPSS1TRIM24
Spitzoid Melanomas​
CEP89LSM14AMYO5APPFIBP1PWWP2A
Soft Tissue Cancer
Clear Cell Sarcomas​
ATF1EWSR1
Congenital (Infantile) Fibrosarcomas​
ETV6NTRK3
Desmoplastic Small Round Cell Tumors​
ERGEWSR1SSX1
Endometrial Stromal Sarcomas​
ALKFN1
Epithelioid Sarcomas​
SS18
Inflammatory Myofibroblastic Tumors​
ALKATICCARSCLTCDCTN1PPFIBP1RANBP2SEC31ATPM3TPM4
Leiomyosarcomas​
EWSR1WT1
Liposarcomas; Myxoid-Round Cell​
DDIT3 (GADD153, CHOP)EWSR1
Liposarcomas; Pleomorphic​
DDIT3 (GADD153, CHOP)FUS
Rhabdoid Tumors​
NCOA4RET
Rhabdomyosarcomas​
FOXO1PAX3PAX7
Sarcomas​
ETV4EWSR1
Small Round Cell Tumors​
ETV1EWSR1FEVFLI1
Solitary Fibrous Tumors​
NAB2STAT6
Synovial Sarcomas​
SS18SSX2SSX2B
Other Fibrosarcomas​
COL1A1PDGFB
Stomach Cancer
Adenocarcinomas​
AKT1ERBB2 (HER-2, NEU)INSR
Thyroid Cancer
Adenoma-Nodule-Goitre​
CCDC6NCOA4PAX8PPARGPRKAR1ARET
Anaplastic Carcinomas​
ALKCCDC6NCOA4RETSTRN
Follicular Carcinomas​
PAX8PPARG
Hurthle Cell Carcinomas​
CCDC6NCOA4RET
Mucoepidermoid Carcinomas​
CRTC1MAML2
Papillary Carcinomas​
AGKAKAP9ALKBRAFCCDC6EML4ERC1ETV6GOLGA5HOOK3KTN1NCOA4NTRK1NTRK3PAX8PCM1PPARGPRKAR1ARETSTRNTFGTPM3TRIM24TRIM27TRIM33
Urinary Tract Cancer
Endometrial Carcinomas​
INSRPIK3CA (p110-alpha)
Transitional Cell Carcinomas​
BAIAP2L1FGFR3TACC3
Uterine Cancer
Endometrial Carcinomas​
INSRPIK3CA (p110-alpha)
Other Hematological Malignancies
Eosinophilia​
ETV6FOXP1LYNPDGFRA
Langerhans Cell Histiocytosis​
NTRK3PLEKHA6
Plasma Cell Myelomas​
ABL1BCR
Polycythemia Vera​
GTF2H3
Severe Thrombocythemia​
KANK1PDGFRB
Other Myeloid Neoplasms
KLF2PTK2B (PYK2)SEMA6A
Other Solid Tumors
Midline Carcinomas​
BRD3BRD4NUTM1WHSC1L1
Squamous Cell Carcinomas (SCC)​
MAST2
Other Solid Tumors​
ARHGAP26BRD3INSRMAST2MSMBMUSKNUMBLNUTM1PDGFRBRSPO2THADA
Other Cancers
Midline Carcinomas​
BRD3BRD4NUTM1WHSC1L1
Squamous Cell Carcinomas (SCC)​
MAST2
Other Cancers​
JAK3
Commercial Control Samples
ALKBAIAP2L1BRAFCCDC6CD74EGFR (ERBB1)EML4ERGETV6FGFR3KIF5BLMNAMETNCOA4NTRK1NTRK3PAX8PPARGRETROS1SEPT14SLC34A2SLC45A3TACC3TFGTMPRSS2TPM3
Checkpoint Molecules
Inhibitory on Tumor Cells​
CD200CD274 (PD-L1)CD274 (PD-L1)CD48CD80CD86ITGAVITGB3LGALS9MICAMICBPDCD1LG2TNFRSF14VSIR
Stimulatory on Tumor Cells​
CD40 (TNFRSF5)CD40LGCD48CD70CD86ICOSLGTNFRSF9TNFSF14TNFSF4 (OX40L)TNFSF9
Inhibitory on T Cells​
BTLACD160CD200R1CD244CD274 (PD-L1)CD274 (PD-L1)CD28CTLA4HAVCR2KLRC1LAG3LILRB1LILRB3PDCD1 (PD1)PDCD1 (PD1)VSIR
Stimulatory on T Cells​
CD244CD27 (TNFRSF7)CD28CD40 (TNFRSF5)CD40LGICOSTNFRSF14TNFRSF18TNFRSF4 (OX40)TNFRSF9TNFSF14TNFSF9
T Cell Receptor Genes​
CD247CD3DCD3ECD3GTRACTRGC2
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB5IFI30
Other Checkpoint Molecules​
ADORA2ABTNL2CD160CD276CD44CD52CD8AHHLA2IDO1 (IDO)IDO1 (IDO)IDO2KIR3DL1KLRD1LAIR1MS4A1NRP1TIGITTMIGD2TNFRSF25 (DR3)TNFRSF8TNFSF15VTCN1
Checkpoint Blockade Therapy Biomarkers
BTLACD274 (PD-L1)CD274 (PD-L1)CD80CD8ACSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)HAVCR2HLA-DRAHLA-DRB1HLA-DRB5ICOSIFNGLAG3PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2
Immuno Regulatory Gene Signature
ERBB2 (HER-2, NEU)FASIL5RA (CD125)INHBATNFRSF8TNFSF4 (OX40L)TNFSF9
Immuno Stimulatory Gene Signature
CD160CD19CD200CD27 (TNFRSF7)CD44CTLA4HLA-AIL12RB2IL17AKIT (CD117)TNFRSF17
Immuno Suppressive Gene Signature
CD274 (PD-L1)CD274 (PD-L1)CD276HAVCR2PDCD1LG2TGFB1
Upregulated in Cancer Vaccination Response
CCL5 (RANTES)CD3DCD86CD8ACXCL10 (INP10)CXCL9 (MIG)GBP1ICOSIRF1KLRD1PSMB9STAT1
Immune Cell Markers
CD8 T Cells​
CD8ACD8BFLT3LGGZMMPRF1
Th1 Cells​
CCL4 (MIP-1B)CD38CD70CSF2 (GM-CSF)CTLA4DPP4IFNGIL12RB2LTA (TNFB)STAT4TBX21
Th17 Cells​
IL17AIL17RARORC
Th2 Cells​
CXCR6GATA3IL26LAIR2MAFPMCHSMAD2 (MADH2)STAT6
Follicular Helper T Cells​
BCL6CXCL13MAFPDCD1 (PD1)PDCD1 (PD1)
Other T Helper Cell Markers​
ANP32BBATFCD28ICOSNUP107
Regulatory T Cells​
FOXP3
Gamma Delta T Cells​
CD160FEZ1TRGC1
Central Memory T Cells​
ATMDOCK9FYB1NEFLREPS1TXKUSP9Y
Effector Memory T Cells​
AKT3CCR2EWSR1IL15RALTKNFATC4 (NFAT3)
Other T Cell Markers​
CD2CD247CD3DCD3ECD3GCD6IL2RBTNFRSF25 (DR3)TRACTRGC2
Myeloid Derived Suppressor Cells​
TGFB1
Cytotoxic Lymphocytes​
CD3ECD3GCD8ACD8BEOMESGZMAGZMBIFNGKLRC1KLRD1NKG7TBX21
Natural Killer Cells​
BCL2CD160FOXJ1FUT5GTF3C1GZMBIL21RKIR3DL1MPPED1NCR1PLA2G6RRADZNF205
Activated Dendritic Cells​
CCL1 (I-309)EBI3LAMP3OAS3
Immature Dendritic Cells​
CD1ACD1BCD1EF13A1SYT17
Myeloid Dendritic Cells​
CD1ACD1BCD1E
Plasmacytoid Dendritic Cells​
IL3RA
Other Dendritic Cell Markers​
CCL13 (MCP-4)CCL17 (TARC)CCL22 (MDC)CD209HSD11B1
Macrophages​
APOECCL7 (MCP-3)CD68CHIT1CXCL5 (ENA-78, LIX)MARCOMSR1
Neutrophils​
CSF3R (GM-CSFR)FPR2MME
Eosinophils​
CCR3IL5RA (CD125)PTGDR2 (CRTH2, GPR44)SMPD3THBS1 (TSP-1)
Mast Cells​
CMA1CTSGKIT (CD117)MS4A2PRG2TPSAB1
B Cells​
BANK1BLKCD19CD79ACR2HLA-DOBHLA-DQA1MS4A1PAX5TNFRSF17
Antigen Presenting Cells​
CMKLR1
Regulatory T Cell Gene Signature
CD274 (PD-L1)CD274 (PD-L1)JAK1PDCD1LG2TIGITTNFRSF18TNFRSF4 (OX40)TNFRSF8TNFRSF9
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors​
CCL5 (RANTES)CX3CL1CXCL10 (INP10)CXCL9 (MIG)ITGB2SELL (LECAM-1)
Other T Cell Trafficking & Infiltration into Tumors Genes​
CCL17 (TARC)CCL4 (MIP-1B)CCR3CCR6CD274 (PD-L1)CD274 (PD-L1)CD44CSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)CXCL13FOXP3IFNGITGA4 (CD49D)ITGB7LTA (TNFB)PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2PTENTNFRSF25 (DR3)TNFSF14
T Cell Exhaustion
Upregulated in T Cell Exhaustion​
CCL5 (RANTES)CD200CD27 (TNFRSF7)CD69CTLA4CXCL10 (INP10)CXCL13GBP1HLA-DMAHLA-DQA1ICOSIFI16IFNGITGAVTAP1 (ABCB2)TIGITTNFRSF9
Downregulated in T Cell Exhaustion​
TNFRSF25 (DR3)
T Cell Exhaustion Transcriptional Nodes​
BATFTBX21
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers​
APPCAPZBCCL4 (MIP-1B)CCL5 (RANTES)CD8ACSNK1ECTLA4CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL9 (MIG)EBI3EHD1GBA2GZMBHLA-DQA1IDO1 (IDO)IDO1 (IDO)IFNGINHBAIRF2NKG7ODF2PHKG2PPIFPRF1SERPINA3SHMT2SIGMAR1SMAD3 (MADH3)TIA1
Suppressed Expression in Responsive Versus Nonresponsive Cancers​
ACTG1BNIP3LCX3CL1FOXN3IFI27JAK1LTA4HNAIPOPTNPRRC2BPTENRBL2TXK
Differentially Expressed in Responsive Versus Nonresponsive Cancers​
ADAM28AKNAAOAHARHGAP9CACNA2D2CARD11CARD16CD109CLEC11ACORO1ACORO1BCXCR4FLT3FMNL1HIVEP1HIVEP2IFI44LIFITM1 (9-27)IGHA1IGHMIGSF6IKZF1ITPKALSM4LST1MAP3K14NFAM1NFKBIL1PLA2G2DPOU2AF1 (OCA-B)PTPRCAPSERPINB9SH3BP5SYTL1TMC8TNFRSF13BTNFRSF19ZFYVE9
Expression Correlates with Positive Objective Response Rates​
CD274 (PD-L1)CD274 (PD-L1)CD276CTLA4HAVCR2IDO1 (IDO)IDO1 (IDO)LAG3PDCD1LG2VTCN1
Upregulated during Treatment​
CD8ACTLA4CXCL10 (INP10)EOMESGZMAGZMBICOSIFNGPRF1
Regulated during Treatment​
IRF1
Pre-Treatment Response Prediction
Predicts Enhanced Response​
ADAM17 (CD156B)MYCRHOCTIMP1
Other Pre-Treatment Response Predictors​
CDK2CDKN2A (P16INK4A)LARGE1NAB2NRAS
Cancer Cell Killing
Inhibits Cancer Cell Killing​
BTLACD274 (PD-L1)CD274 (PD-L1)CD80HAVCR2IDO1 (IDO)IDO1 (IDO)IDO2LAG3MICAMICBPDCD1 (PD1)PDCD1 (PD1)TGFB1VSIRVTCN1
Stimulates Cancer Cell Killing​
IFNG
Antigen Processing & Presentation
Proteasome​
PSMB10PSMB9
Proteases​
IFI30
Endoplasmic Reticulum & Lysosomal Transport​
TAP1 (ABCB2)TAP2 (ABCB3)TAPBPL
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
Immune Cell Receptors & Co-Receptors​
CD8ACD8BKIR3DL1KLRC1KLRD1
Stimulates Antigen Presentation​
CD40 (TNFRSF5)CD40LG
Interferon Gamma Response
Cytokines & Chemokines​
CCL5 (RANTES)IL15RASTAT1
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-H
Major Histocompatibility Complex II Genes​
HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
RNA Degradation​
OAS3
Transcription Factors​
IRF1IRF2
Other Interferon Gamma Response Genes​
CD44GBP1
Cytosolic DNA-Sensing Pathway
Cytokines & Interferons​
CCL4 (MIP-1B)CCL5 (RANTES)CXCL10 (INP10)
Oncogenes
ABL1AKT1ALKARBCL2BRAFCBLCTNNB1DNMT3AEGFR (ERBB1)ERBB2 (HER-2, NEU)EZH2FGFR2FGFR3FLT3FOXL2GATA2GNA11GNAQGNASH3-3AH3C2HRASIDH1IDH2JAK1JAK2JAK3KIT (CD117)KRASMAP2K1MED12METMPLMYD88NFE2L2NRASPDGFRAPIK3CA (p110-alpha)PPP2R1APTPN11RETSETBP1SF3B1SMOSPOPSRCSRSF2TSHRU2AF1
Tumor Suppressor Genes
ACVR1BAMER1APCARID1AARID2ASXL1ATMB2MBCORCDKN2A (P16INK4A)CICCREBBP (CBP)DAXXFBXW7KMT2DMLH1NOTCH2PAX5PBRM1PIK3R1 (p85-ALPHA)PTENRUNX1 (AML1)SMAD2 (MADH2)SMAD4 (MADH4)SMARCB1STK11 (LKB1)WT1
Cell Adhesion Molecules
ABL1APCCSF3R (GM-CSFR)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)JAK2PDGFRAPTENPTPN11RAC1RETRHOASRC
Angiogenesis
CTNNB1ERBB2 (HER-2, NEU)FGFR2GATA2PIK3CA (p110-alpha)PLCG1PTENRUNX1 (AML1)
Apoptosis
ABL1APCBCL2BRAFCBLCTNNB1DAXXFLT3FOXL2HRASID3MYCNPTENRAD21RAF1STK11 (LKB1)WT1
Cell Cycle
ABL1AKT1APCCDKN2A (P16INK4A)CHEK2 (RAD53)CREBBP (CBP)CUX1FBXW7FGFR2HRASID3MYCPTENRAD21RHOASMARCB1STK11 (LKB1)XPO1
DNA Damage & Repair
ABL1APCATMCHEK2 (RAD53)MLH1POLERAD21STK11 (LKB1)
Epigenetics
ARID1AARID2ASXL1BCORDICER1DNMT3AEZH2H3-3AH3C2KMT2DNSD2PBRM1SETBP1SMARCB1SPOP
Hypoxia Signaling
CREBBP (CBP)EPAS1SMAD4 (MADH4)
Immune Response
ALKB2MBTKCBLBCD79BCREBBP (CBP)CXCR4JAK1JAK2JAK3MAP2K1MAP2K2 (MEK2)MYD88PAX5PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENPTPN11
Inflammatory Response
CXCR4JAK2MYD88
Metabolism
IDH1IDH2
mRNA Splicing
SF3B1SRSF2U2AF1ZRSR2
Signal Transduction
AKT & PI3 Kinase Signaling​
AKT1CBLERBB2 (HER-2, NEU)FLT3JAK2KIT (CD117)PDGFRAPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTEN
Fibroblast Growth Factor Signaling​
AKT1FGFR1FGFR2FGFR3FGFR4PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENPTPN11SRC
G-Protein Coupled Receptor Signaling​
AKT1GNA11GNAQGNASSMOTSHR
Hormone Receptors​
ARESR1 (ERα)
JAK / STAT Signaling​
JAK1JAK2JAK3STAT3
MAP Kinase Signaling​
MAP2K1MAP2K2 (MEK2)MAPK1 (ERK2)NRASPPM1DRAF1
Notch Signaling​
FBXW7GATA2NOTCH2
Receptor Tyrosine Kinases​
ALKEGFR (ERBB1)ERBB2 (HER-2, NEU)ERBB3FGFR1FGFR4FLT3KIT (CD117)PDGFRARET
TGFb Signaling​
ACVR1BSMAD2 (MADH2)
WNT Signaling​
AMER1APCCTNNB1MED12PPP2R1A
Other Signal Transduction Genes​
KRASMETSMAD4 (MADH4)
Transcription Factors
ARCICCUX1ESR1 (ERα)FBXW7FOXL2GATA2ID3MYCMYCNNFE2L2NKX2-1PAX5RUNX1 (AML1)WT1
Ubiquitination
BCORCBLBDAXX
Unfolded Protein Response
NFE2L2
Other Cancer Related Genes
DNM2MPLPRSS1TERT

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