RNA Fusion XP Oncology Research Panel

Bone Cancer

Askins Tumors

ERGEWSR1FLI1FUS

Ewing's Sarcomas

ERGETV1ETV4EWSR1FEVFLI1FUSNFATC2SMARCA5

Giant Cell Tumors

EWSR1FLI1

Mesenchymal Chondrosarcomas

CDX1HEY1IRF2BP2NCOA2

Myxoid Chondrosarcomas

EWSR1NR4A3TAF15TCF12TFG

Brain Cancer

Gliomas

AKT2BRAFCLCN6FAM131BFGFR1FGFR3FIP1L1GNAI1GOPCMKRN1MYBPDGFRAPRKCBRAF1RNF130ROS1SRGAP3TACC1TACC3

Neuroblastomas

EWSR1FLI1

Pilocytic Astrocytomas

CLCN6FAM131BGNAI1MKRN1RNF130SRGAP3TACC1

Other Brain Cancers

EWSR1FLI1NAB2PDGFRAPRKCASTAT6

Breast Cancer

Carcinomas

AKT2BRD3DAZLETV6FGFR1JAK1KITMAST1MAST2NTRK3PIK3CARAF1TBL1XR1ZC3H7BZNF703

Ductal Carcinomas

DAZLETV6NTRK3

Other Breast Cancers

AKT3ESR1NOTCH2

Colorectal Cancer

Adenocarcinomas

ETV6INSRNTRK1NTRK3TCF7L2TPM3VTI1A

Kidney Cancer

Carcinomas

ALKASPSCR1PRCCTFE3VCL

Clear Cell Sarcomas

TERT

Mesoblastic Nephromas

ETV6NTRK3

Renal Cell Carcinomas

TFEBVCL

Leukemia

Acute Leukemia of Ambiguous Lineage

ABL1AFF1BCRCT45A2ETV6EWSR1GPHNKMT2AMLLT10MN1NUP214PBX1SETTCF3ZNF384

Acute Myelomonocytic Leukemia (AMML)

FLNAHOXD13NUP98

B-Cell Acute Lymphoblastic Leukemia (B-ALL)

ABL1ACTN4AFF1AFF3AFF4ATF7IPBCRBTBD18CRLF2EPS15ERGESRRBETV6EWSR1FUSGAS7JAK2KMT2AMAPRE1MLLT1NUP214P2RY8PAX5PBX1PCM1RUNX1SETSSBP2TCF3USP9XZNF384ZNF521

Blast Phase Chronic Myeloid Leukemia

ABL1BCRETV6JAK2

Chronic Eosinophilic Leukemia

ACSL6TNIP1

Chronic Lymphocytic Leukemia (CLL)

MYCNOTCH1

Chronic Myeloid Leukemia (CML)

ABL1BCRCCDC88CETV6HOXA11HOXA13JAK2MECOMMN1NDE1NUP98PCM1PDGFRBRUNX1

Chronic Myelomonocytic Leukemia (CMML)

CREBBPELLETV6KMT2AMN1

Myelodysplastic Syndromes (MDS)

ABL1ACTN4ALKCASC5CREBBPDEKERGETV6FRYLFUSHOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1NDE1NPM1NUP214NUP98PCM1PDGFRBPRDM16PTPRRRANBP2RUNX1RUNX1T1TOP1

Myeloproliferative Neoplasms

ABL1ACSL6BCRETV6FGFR1FGFR1OPFIP1L1FLT3HOXA9HOXD13JAK2LYNMECOMMLF1MN1NPM1NUP98PDGFRBPRKG2PSIP1RARARUNX1TNIP1ZMYM2

T-Cell Acute Lymphoblastic Leukemia (T-ALL)

ABL1AFDNAGGF1ASNSBCL11BBCRCASC5DDX3XETV6JAK2KMT2AKMT2EMLLT1MLLT10NOTCH1NUP214PBX1RUNX1SALL2SETSPI1STILSTMN1TAL1TCF3TCF7

Other Leukemias

BCL11BIKZF2IKZF3IRF2BP2MYCNPM1PDCD1LG2SETD2TYK2

Liver Cancer

Cholangiocarcinomas

CCDC6FGFR2TACC3

Hepatocellular Carcinomas

PKN1

Lung Cancer

Acinar Adenocarcinomas

ALKCD74EML4HIP1KIF5BROS1SDC4

Bronchioloalveolar Adenocarcinomas

ALKEML4KLC1PBX1ROS1SDC4TCF3

Inflammatory Myofibroblastic Tumors

ALKCD74EML4EZRGOPCLRIG3PPFIBP1ROS1SDC4SLC34A2TPM3

Invasive Mucinous Adenocarcinomas

ALKCD74EML4NRG1SLC3A2

Mixed Adenosquamous Carcinomas

ALKEML4KIF5BRET

Mucoepidermoid Carcinomas

ALKCRTC1EML4MAML2

Non-Small Cell Carcinomas

ALKBCL11ACCDC6CD74CUX1EGFREML4EZRGCC2GOPCHIP1KIAA1217KIF5BKLC1LRIG3NCOA4RETROS1SDC4SLC34A2STRNTFGTPM3TPRTRIM33

Squamous Cell Carcinomas (SCC)

ALKBAIAP2L1CD74EML4FGFR2FGFR3FGRHIP1KIF5BKITNRG1PKN1PRKCAPRKCBRETTACC3

Other Carcinomas

ALKBRD4EML4NUTM1

Other Lung Cancers

ARL17ABAG4BAIAP2L1CCDC6CD74CUX1EZRFGFR1FGFR3GOPCIRF2BP2KANSL1KIAA1217KIF5BLRIG3MPRIPNCOA4NRG1NTRK1NUTM1PTPRKRETROS1RSPO3SDC4SLC34A2SLC3A2SQSTM1TACC3TPM3TPRTRIM33WHSC1L1

Lymphoma

Acute Lymphoblastic Lymphomas

BCL11BCREBBPEBF1KMT2AMLLT10MYCP2RY8PRDM16STIL

Anaplastic Large Cell Lymphomas

ADGRG7ALKATICCLTCMSNMYCNPM1TFGTPM3TPM4

Angioimmunoblastic T Cell Lymphomas

CD28CTLA4FIP1L1PDGFRA

Burkitt Lymphomas

BCL6MYCPBX1TCF3

Diffuse Large B Cell Lymphomas (DLBCL)

ALKBCL11ABCL6CCND3CIITACLTCIGLL5LPPMAPK13MYCNPM1PIM1RELSQSTM1TBL1XR1TOMM40TP63ZCCHC7

Follicular Lymphomas

AFF3BCL2BCL6CIITAMYCTBL1XR1TP63

Granulocytic Sarcomas

RUNX1RUNX1T1

Hodgkin Lymphomas

ALKCIITAJAK2NPM1SEC31A

Inflammatory Myofibroblastic Tumors

ALKCARSDCTN1

Lymphoblastic Lymphomas

BCRCRLF2EPORETV6FGFR1NOTCH1PBX1PDGFRBRARATERTZCCHC7

Lymphoblastic T Cell Lymphomas

BCRETV6FGFR1FIP1L1LYNPDGFRA

Mantle Cell Lymphomas

CCND3MYC

Mediastinal Large B Cell Lymphomas (MLBL)

CIITAPDCD1LG2

Mediastinal Large B-Cell Lymphomas

CIITAPDCD1LG2

Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas

BCL6BIRC3CCND3MALT1MYC

Peripheral T Cell Lymphomas

ALKETV6FGFR3IKZF2ITKMYO1FNPM1S100A7SYKTBL1XR1THAP4TP63VAV1

Precursor T Cell Lymphoblastic Lymphomas

ABL1JAK2NUP214PCM1SET

T Cell Lymphomas

ATXN2LBCL11BFGFR1IKZF2JAK2

Other Lymphomas

ALKATXN2LBCL6BIRC3CBFBCCND1CCND3CDK6CHIC2CLTCDEKDUSP22EIF4A1JAK2KMT2AMALT1MKL1MLF1MLLT10MYCNFKB2NPM1PICALMPRDM16

Myelodysplastic Syndromes (MDS)

ABL1ACTN4ALKCASC5CREBBPDEKDIAPH2ERGETV6FGFR1FRYLFUSGOT1HOXA11HOXA13HOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1MYH11NDE1NPM1NUP214NUP98PAN3PCM1PDGFRBPRDM16PSMA2PTPRRRANBP2RUNX1RUNX1T1SEPT9SYKTOP1ZMYM2

Myeloproliferative Neoplasms

ABL1ACSL6BCRCNTRLETV6FGFR1FGFR1OPFIP1L1FLT3FOXP1HOXA9HOXD13JAK2KANK1LYNMECOMMLF1MN1NPM1NUP98PCM1PDGFRAPDGFRBPRKG2PSIP1RARARUNX1TNIP1

Ovarian Cancer

Carcinomas

ESRRA

Serous Cyst Adenocarcinomas

AKT2AXLFGRINSRJAK1

Pancreatic Cancer

Acinar Cell Carcinomas

GATMHACL1HERPUD1SND1ZSCAN30

Adenocarcinomas

ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2KRASNDRG1PIK3CARAF1SLC45A3TBL1XR1TMPRSS2UBE2L3

Carcinomas

BRAFRAF1

Prostate Cancer

Adenocarcinomas

ACSL3ACVR2AAKT3BRAFCANT1DDX5ELK4ERGESRP1ETV1ETV4ETV5HNRNPA2B1KLK2KRASNDRG1PIK3CARAF1SLC45A3TBL1XR1TMPRSS2UBE2L3

Glandular Intraepithelial Neoplasia

ERGTMPRSS2

Other Carcinomas

ERGETV1TMPRSS2

Salivary Gland Cancer

Adenomas

FGFR1PLAG1

Mucoepidermoid Carcinomas

CRTC1MAML2

Warthin Tumors

CRTC1MAML2

Other Carcinomas

ETV6NTRK3

Other Salivary Gland Cancers

MYB

Sarcoma

Alveolar Soft Part Sarcomas

ASPSCR1TFE3

Angiosarcomas & Epitheliod Haemangioendotheliomas

CAMTA1CEP85LCICLEUTXROS1TFE3YAP1

Askins Tumors

ERGEWSR1FLI1FUS

Chondrosarcomas

ACVR2ACDX1EWSR1FN1HEY1IRF2BP2NCOA2NR4A3TAF15TCF12TFG

Clear Cell Sarcomas

ATF1CREB1EWSR1FLI1NUTM2BYWHAE

Congenital (Infantile) Fibrosarcomas

ETV6METNTRK3TFG

Dermatofibrosarcoma Protuberans

COL1A1PDGFB

Dermatofibrosarcomas Protuberans

COL1A1PDGFB

Desmoplastic Small Round Cell Tumors

ERGEWSR1FLI1PATZ1WT1

Endometrial Stromal Sarcomas

ALKBCORCXorf67EPC1FN1JAZF1MBTD1MEAF6NUTM2ANUTM2BPHF1SUZ12YWHAEZC3H7B

Epithelioid Sarcomas

CREB3L1CREB3L2EWSR1FUSKLF17SS18SSX1

Ewing's Sarcomas

CICERGETV1ETV4EWSR1FEVFLI1FOXO4FUSNFATC2SMARCA5SP3

Fibrosarcomas

BRAFCOL1A1CREB3L1CREB3L2EWSR1FUSLMNANTRK1PDGFBTOM1L2

Leiomyosarcomas

EWSR1HMGA2PBX3WT1

Liposarcomas

DDIT3EWSR1FUSHMGA2LGR5NUP107TERT

Myofibroblastic Sarcomas

ALKLMNANTRK1RELAROS1SRFTFGTPM3YWHAE

Myxofibrosarcomas

CREB3L1CREB3L2FUS

Myxoid Chondrosarcomas

NR4A3TAF15

Perivascular Epithelioid Cell Tumors (PEComa)

DVL2SFPQTFE3

Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)

CITED2MED12PRDM10

Rhabdoid Tumors

NCOA4RET

Rhabdomyosarcomas

CITED2EWSR1FLI1FOXO1NCOA1NCOA2PAX3PAX7SRFTEAD1VGLL2

Small Round Cell Tumors

ERGETV1EWSR1FEVFLI1FOXO1PAX3

Solitary Fibrous Tumors

NAB2STAT6

Synovial Sarcomas

COL6A3CSF1S100A10SS18SS18L1SSX1SSX2SSX2BSSX4B

Undifferentiated; Unclassified or Other Sarcomas

ATF1BCORBRD4CCNB3CREMERGETV4EWSR1FGF1FGFR1FLI1FN1FOXO1FUSGLI1JAZF1MAML3MKL2NPM1NUTM1PAX3PLAG1POU5F1RUNX1RUNX1T1SUZ12USP6

Skin Cancer

Adnexal Tumors; Hidradenomas

CRTC1MAML2

Atypical Spitzoid Tumors

ALKTPM3

Benign Melanocytic Nevus

ALKBRAFCEP89ERC1FCHSD1GOLGA5KIF5BLSM14AMYO5APPFIBP1PWWP2ARETROS1TPM3

Melanomas

AGKATF1BRAFCREB1EWSR1FCHSD1FGRPAPSS1TRIM24

Spitzoid Melanomas

CEP89LSM14AMYO5APPFIBP1PWWP2A

Soft Tissue Cancer

Clear Cell Sarcomas

ATF1EWSR1

Congenital (Infantile) Fibrosarcomas

ETV6NTRK3

Desmoplastic Small Round Cell Tumors

ERGEWSR1SSX1

Endometrial Stromal Sarcomas

ALKFN1

Epithelioid Sarcomas

SS18

Inflammatory Myofibroblastic Tumors

ALKATICCARSCLTCDCTN1PPFIBP1RANBP2SEC31ATPM3TPM4

Leiomyosarcomas

EWSR1WT1

Liposarcomas; Myxoid-Round Cell

DDIT3EWSR1

Liposarcomas; Pleomorphic

Rhabdoid Tumors

Rhabdomyosarcomas

Sarcomas

Small Round Cell Tumors

ETV1EWSR1FEVFLI1

Solitary Fibrous Tumors

NAB2STAT6

Synovial Sarcomas

SS18SSX2SSX2B

Other Fibrosarcomas

COL1A1PDGFB

Stomach Cancer

Adenocarcinomas

AKT1ERBB2INSR

Thyroid Cancer

Adenoma-Nodule-Goitre

CCDC6NCOA4PAX8PPARGPRKAR1ARET

Anaplastic Carcinomas

ALKCCDC6NCOA4RETSTRN

Follicular Carcinomas

PAX8PPARG

Hurthle Cell Carcinomas

CCDC6NCOA4RET

Mucoepidermoid Carcinomas

CRTC1MAML2

Papillary Carcinomas

AGKAKAP9ALKBRAFCCDC6EML4ERC1ETV6GOLGA5HOOK3KTN1NCOA4NTRK1NTRK3PAX8PCM1PPARGPRKAR1ARETSTRNTFGTPM3TRIM24TRIM27TRIM33

Urinary Tract Cancer

Endometrial Carcinomas

INSRPIK3CA

Transitional Cell Carcinomas

BAIAP2L1FGFR3TACC3

Uterine Cancer

Endometrial Carcinomas

INSRPIK3CA

Other Hematological Malignancies

Eosinophilia

ETV6FOXP1LYNPDGFRA

Langerhans Cell Histiocytosis

NTRK3PLEKHA6

Plasma Cell Myelomas

ABL1BCR

Polycythemia Vera

GTF2H3

Severe Thrombocythemia

KANK1PDGFRB

Other Myeloid Neoplasms

KLF2PTK2BSEMA6A

Other Solid Tumors

Midline Carcinomas

BRD3BRD4NUTM1WHSC1L1

Squamous Cell Carcinomas (SCC)

MAST2

Other Solid Tumors

ARHGAP26BRD3INSRMAST2MSMBMUSKNUMBLNUTM1PDGFRBRSPO2THADA

Other Cancers

Midline Carcinomas

BRD3BRD4NUTM1WHSC1L1

Squamous Cell Carcinomas (SCC)

MAST2

Other Cancers

JAK3

Commercial Control Samples

ALKBAIAP2L1BRAFCCDC6CD74EGFREML4ERGETV6FGFR3KIF5BLMNAMETNCOA4NTRK1NTRK3PAX8PPARGRETROS1SEPT14SLC34A2SLC45A3TACC3TFGTMPRSS2TPM3

Checkpoint Molecules

Inhibitory on Tumor Cells

CD200CD274CD274CD48CD80CD86ITGAVITGB3LGALS9MICAMICBPDCD1LG2TNFRSF14VSIR

Stimulatory on Tumor Cells

CD40CD40LGCD48CD70CD86ICOSLGTNFRSF9TNFSF14TNFSF4TNFSF9

Inhibitory on T Cells

BTLACD160CD200R1CD244CD274CD274CD28CTLA4HAVCR2KLRC1LAG3LILRB1LILRB3PDCD1PDCD1VSIR

Stimulatory on T Cells

CD244CD27CD28CD40CD40LGICOSTNFRSF14TNFRSF18TNFRSF4TNFRSF9TNFSF14TNFSF9

T Cell Receptor Genes

CD247CD3DCD3ECD3GTRACTRGC2

Major Histocompatibility Complex I Genes

B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1

Major Histocompatibility Complex II Genes

CD74HLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB5IFI30

Other Checkpoint Molecules

ADORA2ABTNL2CD160CD276CD44CD52CD8AHHLA2IDO1IDO1IDO2KIR3DL1KLRD1LAIR1MS4A1NRP1TIGITTMIGD2TNFRSF25TNFRSF8TNFSF15VTCN1

Checkpoint Blockade Therapy Biomarkers

BTLACD274CD274CD80CD8ACSF2CXCL11HAVCR2HLA-DRAHLA-DRB1HLA-DRB5ICOSIFNGLAG3PDCD1PDCD1PDCD1LG2

Immuno Regulatory Gene Signature

ERBB2FASIL5RAINHBATNFRSF8TNFSF4TNFSF9

Immuno Stimulatory Gene Signature

CD160CD19CD200CD27CD44CTLA4HLA-AIL12RB2IL17AKITTNFRSF17

Immuno Suppressive Gene Signature

CD274CD274CD276HAVCR2PDCD1LG2TGFB1

Upregulated in Cancer Vaccination Response

CCL5CD3DCD86CD8ACXCL10CXCL9GBP1ICOSIRF1KLRD1PSMB9STAT1

Immune Cell Markers

CD8 T Cells

CD8ACD8BFLT3LGGZMMPRF1

Th1 Cells

CCL4CD38CD70CSF2CTLA4DPP4IFNGIL12RB2LTASTAT4TBX21

Th17 Cells

IL17AIL17RARORC

Th2 Cells

CXCR6GATA3IL26LAIR2MAFPMCHSMAD2STAT6

Follicular Helper T Cells

BCL6CXCL13MAFPDCD1PDCD1

Other T Helper Cell Markers

ANP32BBATFCD28ICOSNUP107

Regulatory T Cells

FOXP3

Gamma Delta T Cells

CD160FEZ1TRGC1

Central Memory T Cells

ATMDOCK9FYB1NEFLREPS1TXKUSP9Y

Effector Memory T Cells

AKT3CCR2EWSR1IL15RALTKNFATC4

Other T Cell Markers

CD2CD247CD3DCD3ECD3GCD6IL2RBTNFRSF25TRACTRGC2

Myeloid Derived Suppressor Cells

TGFB1

Cytotoxic Lymphocytes

CD3ECD3GCD8ACD8BEOMESGZMAGZMBIFNGKLRC1KLRD1NKG7TBX21

Natural Killer Cells

BCL2CD160FOXJ1FUT5GTF3C1GZMBIL21RKIR3DL1MPPED1NCR1PLA2G6RRADZNF205

Activated Dendritic Cells

CCL1EBI3LAMP3OAS3

Immature Dendritic Cells

CD1ACD1BCD1EF13A1SYT17

Myeloid Dendritic Cells

CD1ACD1BCD1E

Plasmacytoid Dendritic Cells

IL3RA

Other Dendritic Cell Markers

CCL13CCL17CCL22CD209HSD11B1

Macrophages

APOECCL7CD68CHIT1CXCL5MARCOMSR1

Neutrophils

CSF3RFPR2MME

Eosinophils

CCR3IL5RAPTGDR2SMPD3THBS1

Mast Cells

CMA1CTSGKITMS4A2PRG2TPSAB1

B Cells

BANK1BLKCD19CD79ACR2HLA-DOBHLA-DQA1MS4A1PAX5TNFRSF17

Antigen Presenting Cells

CMKLR1

Regulatory T Cell Gene Signature

CD274CD274JAK1PDCD1LG2TIGITTNFRSF18TNFRSF4TNFRSF8TNFRSF9

T Cell Trafficking & Infiltration into Tumors

Stimulates T Cell Trafficking & Infiltration into Tumors

CCL5CX3CL1CXCL10CXCL9ITGB2SELL

Other T Cell Trafficking & Infiltration into Tumors Genes

CCL17CCL4CCR3CCR6CD274CD274CD44CSF2CXCL11CXCL13FOXP3IFNGITGA4ITGB7LTAPDCD1PDCD1PDCD1LG2PTENTNFRSF25TNFSF14

T Cell Exhaustion

Upregulated in T Cell Exhaustion

CCL5CD200CD27CD69CTLA4CXCL10CXCL13GBP1HLA-DMAHLA-DQA1ICOSIFI16IFNGITGAVTAP1TIGITTNFRSF9

Downregulated in T Cell Exhaustion

TNFRSF25

T Cell Exhaustion Transcriptional Nodes

BATFTBX21

Responsiveness or Response Biomarkers

Enhanced Expression in Responsive Versus Nonresponsive Cancers

APPCAPZBCCL4CCL5CD8ACSNK1ECTLA4CXCL10CXCL11CXCL9EBI3EHD1GBA2GZMBHLA-DQA1IDO1IDO1IFNGINHBAIRF2NKG7ODF2PHKG2PPIFPRF1SERPINA3SHMT2SIGMAR1SMAD3TIA1

Suppressed Expression in Responsive Versus Nonresponsive Cancers

ACTG1BNIP3LCX3CL1FOXN3IFI27JAK1LTA4HNAIPOPTNPRRC2BPTENRBL2TXK

Differentially Expressed in Responsive Versus Nonresponsive Cancers

Expression Correlates with Positive Objective Response Rates

CD274CD274CD276CTLA4HAVCR2IDO1IDO1LAG3PDCD1LG2VTCN1

Upregulated during Treatment

CD8ACTLA4CXCL10EOMESGZMAGZMBICOSIFNGPRF1

Regulated during Treatment

IRF1

Pre-Treatment Response Prediction

Predicts Enhanced Response

ADAM17MYCRHOCTIMP1

Other Pre-Treatment Response Predictors

CDK2CDKN2ALARGE1NAB2NRAS

Cancer Cell Killing

Inhibits Cancer Cell Killing

BTLACD274CD274CD80HAVCR2IDO1IDO1IDO2LAG3MICAMICBPDCD1PDCD1TGFB1VSIRVTCN1

Stimulates Cancer Cell Killing

IFNG

Antigen Processing & Presentation

Proteasome

PSMB10PSMB9

Proteases

IFI30

Endoplasmic Reticulum & Lysosomal Transport

TAP1TAP2TAPBPL

Major Histocompatibility Complex I Genes

B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1

Major Histocompatibility Complex II Genes

CD74HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30

Immune Cell Receptors & Co-Receptors

CD8ACD8BKIR3DL1KLRC1KLRD1

Stimulates Antigen Presentation

CD40CD40LG

Interferon Gamma Response

Cytokines & Chemokines

CCL5IL15RASTAT1

Major Histocompatibility Complex I Genes

B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-H

Major Histocompatibility Complex II Genes

HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30

RNA Degradation

OAS3

Transcription Factors

IRF1IRF2

Other Interferon Gamma Response Genes

CD44GBP1

Cytosolic DNA-Sensing Pathway

Cytokines & Interferons

CCL4CCL5CXCL10

Oncogenes

Tumor Suppressor Genes

ACVR1BAMER1APCARID1AARID2ASXL1ATMB2MBCORCDKN2ACICCREBBPDAXXFBXW7KMT2DMLH1NOTCH2PAX5PBRM1PIK3R1PTENRUNX1SMAD2SMAD4SMARCB1STK11WT1

Cell Adhesion Molecules

ABL1APCCSF3RCTNNB1EGFRERBB2JAK2PDGFRAPTENPTPN11RAC1RETRHOASRC

Angiogenesis

CTNNB1ERBB2FGFR2GATA2PIK3CAPLCG1PTENRUNX1

Apoptosis

ABL1APCBCL2BRAFCBLCTNNB1DAXXFLT3FOXL2HRASID3MYCNPTENRAD21RAF1STK11WT1

Cell Cycle

ABL1AKT1APCCDKN2ACHEK2CREBBPCUX1FBXW7FGFR2HRASID3MYCPTENRAD21RHOASMARCB1STK11XPO1

DNA Damage & Repair

ABL1APCATMCHEK2MLH1POLERAD21STK11

Epigenetics

ARID1AARID2ASXL1BCORDICER1DNMT3AEZH2H3-3AH3C2KMT2DNSD2PBRM1SETBP1SMARCB1SPOP

Hypoxia Signaling

CREBBPEPAS1SMAD4

Immune Response

ALKB2MBTKCBLBCD79BCREBBPCXCR4JAK1JAK2JAK3MAP2K1MAP2K2MYD88PAX5PIK3CAPIK3R1PTENPTPN11

Inflammatory Response

CXCR4JAK2MYD88

Metabolism

IDH1IDH2

mRNA Splicing

SF3B1SRSF2U2AF1ZRSR2

Signal Transduction

AKT & PI3 Kinase Signaling

AKT1CBLERBB2FLT3JAK2KITPDGFRAPIK3CAPIK3R1PTEN

Fibroblast Growth Factor Signaling

AKT1FGFR1FGFR2FGFR3FGFR4PIK3CAPIK3R1PTENPTPN11SRC

G-Protein Coupled Receptor Signaling

AKT1GNA11GNAQGNASSMOTSHR

Hormone Receptors

ARESR1

JAK / STAT Signaling

JAK1JAK2JAK3STAT3

MAP Kinase Signaling

MAP2K1MAP2K2MAPK1NRASPPM1DRAF1

Notch Signaling

FBXW7GATA2NOTCH2

Receptor Tyrosine Kinases

ALKEGFRERBB2ERBB3FGFR1FGFR4FLT3KITPDGFRARET

TGFb Signaling

ACVR1BSMAD2

WNT Signaling

AMER1APCCTNNB1MED12PPP2R1A

Other Signal Transduction Genes

KRASMETSMAD4

Transcription Factors

ARCICCUX1ESR1FBXW7FOXL2GATA2ID3MYCMYCNNFE2L2NKX2-1PAX5RUNX1WT1

Ubiquitination

BCORCBLBDAXX

Unfolded Protein Response

NFE2L2

Other Cancer Related Genes

DNM2MPLPRSS1TERT

RNA Fusion XP Oncology Research Panel

Select a variant to see the price

Product Specification

Target List

Product Resources

Resources

RNA Fusion XP Oncology Research Panel

Select a variant to see the price help_outline

Product Specification

Target List

Product Resources

Resources

Select a variant to see the price