Target List
Hotspot Coverage
ALKBRAFCDKN2A (P16INK4A)CTNNB1KIT (CD117)MAP2K1NF2NRASNTRK1PIK3CA (p110-alpha)PTENRB1RETROS1TSC2
Whole Coding Coverage
EGFR (ERBB1)ERBB2 (HER-2, NEU)KRASMETTP53 (p53)
Adenocarcinomas
ALKBRAFCDKN2A (P16INK4A)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)KRASMAP2K1METNRASNTRK1PIK3CA (p110-alpha)PTENRETROS1TP53 (p53)TSC2
Carcinomas
ALKBRAFCTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)KIT (CD117)KRASMAP2K1METNRASPIK3CA (p110-alpha)RET
Non-Small Cell Lung Cancers (NSCLC)
ALKBRAFCDKN2A (P16INK4A)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)KIT (CD117)KRASMAP2K1METNRASPIK3CA (p110-alpha)PTENRETROS1TP53 (p53)
Small Cell Lung Cancers (SCLC)
ALKBRAFCTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)KIT (CD117)KRASMAP2K1METNRASNTRK1PIK3CA (p110-alpha)PTENRB1RETTP53 (p53)
Squamous Cell Carcinomas
ALKBRAFCDKN2A (P16INK4A)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)KIT (CD117)KRASMAP2K1METNRASNTRK1PIK3CA (p110-alpha)PTENRETROS1TP53 (p53)TSC2
Other Lung Cancer Genes
ALKBRAFCTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)KIT (CD117)KRASMAP2K1METNF2NRASNTRK1PIK3CA (p110-alpha)RET