Target List
Anaplastic Glial Tumors
CDKN2A (P16INK4A)CDKN2B (p15INK4b)MDM2PTENRB1TP53 (p53)
Astrocytomas
ATRXBRAFCHEK2 (RAD53)FGFR1IDH1IDH2KRASNOTCH1PTPN11RB1TP53 (p53)
Ependymomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)H3-3ANF2NOTCH1
Glioblastomas
ALKAPCBCORBRAFCDK4CDK6CDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)EGFR (ERBB1)ERBB2 (HER-2, NEU)FGFR3H3-3AH3C2IDH1IDH2KIT (CD117)MDM2METMLH1MSH2MTORMYCNOTCH1NRASPIK3CA (p110-alpha)PMS2PTENRB1STK11 (LKB1)TERTTP53 (p53)
Gliomas
ACVR1 (ALK2)BRCA2CHEK2 (RAD53)FGFR1H3-3APDGFRAPIK3CA (p110-alpha)PTENTP53 (p53)
High-Grade Gliomas
ATRXBRAFCICEGFR (ERBB1)FUBP1IDH1IDH2
Medulloblastomas
BRCA2CDK4CREBBP (CBP)CTNNB1FGFR1GLI2IDH1IDH2MSH2MYCMYCNNRASPIK3CA (p110-alpha)PTCH2SMARCA4SMARCB1SUFUTP53 (p53)
Meningiomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)NF2PTEN
Oligodendrogliomas
IDH1IDH2MSH2NOTCH1TERT