Target List
Brain Cancers
Anaplastic Glial Tumors
CDKN2A (P16INK4A)CDKN2B (p15INK4b)MDM2PTENRB1TP53 (p53)
Astrocytomas
ATRXBRAFCHEK2 (RAD53)FGFR1IDH1IDH2KRASNOTCH1PTPN11RB1TP53 (p53)
Ependymomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)H3-3ANF2NOTCH1
Glioblastomas
ALKAPCBCORBRAFCDK4CDK6CDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)EGFR (ERBB1)ERBB2 (HER-2, NEU)FGFR3H3-3AH3C2IDH1IDH2KIT (CD117)MDM2METMLH1MSH2MTORMYCNOTCH1NRASPIK3CA (p110-alpha)PMS2PTENRB1STK11 (LKB1)TERTTP53 (p53)
Gliomas
ACVR1 (ALK2)BRCA2CHEK2 (RAD53)FGFR1H3-3APDGFRAPIK3CA (p110-alpha)PTENTP53 (p53)
High-Grade Gliomas
ATRXBRAFCICEGFR (ERBB1)FUBP1IDH1IDH2
Medulloblastomas
BRCA2CDK4CREBBP (CBP)CTNNB1FGFR1GLI2IDH1IDH2MSH2MYCMYCNNRASPIK3CA (p110-alpha)PTCH2SMARCA4SMARCB1SUFUTP53 (p53)
Meningiomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)NF2PTEN
Oligodendrogliomas
IDH1IDH2MSH2NOTCH1TERT
Breast Cancers
Carcinomas
ATMBARD1BRCA1BRCA2BRIP1CDK12CDK4CHEK1CHEK2 (RAD53)EGFR (ERBB1)ERBB2 (HER-2, NEU)ESR1 (ERα)FANCLKIT (CD117)KRASMETMLH1MLH3MSH2MSH3MSH6PALB2PDGFRAPIK3CA (p110-alpha)PMS1PMS2RAD51BRAD51CRAD51DRAD54L
Ductal Carcinomas
ARCCND1CDH1 (E-Cadherin)CYP2D6FANCD2FBXW7FGFR1FGFR2MRE11MYCNBNNTRK3PPM1DPPP2R1ARB1CC1SF3B1SLC22A18STK11 (LKB1)TP53 (p53)
ER-Positive Carcinomas
CDH1 (E-Cadherin)RB1CC1SF3B1
HER-Positive Carcinomas
ARCCND1FANCD2NTRK3PPM1DRB1CC1
Metastatic Breast Cancers
AKT1BRCA1BRCA2ERBB2 (HER-2, NEU)ERBB3ESR1 (ERα)MDM2NF1PALB2PIK3CA (p110-alpha)PTEN
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2
Colorectal Cancers
Adenocarcinomas
APCARID1AATMAXIN2BARD1BAXBMPR1A (ALK3)BRAFBRCA1BRCA2BRIP1BUB1BUB1BCDK12CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)CTNNB1DCCDLC1EGFR (ERBB1)EP300ERBB2 (HER-2, NEU)ERBB3ESR1 (ERα)FANCLFBXW7FGFR1FGFR3FLCNGNASHRASKIT (CD117)KRASMAP2K1MCCMETMLH1MLH3MSH2MSH3MSH6MUTYHMYCNRASPALB2PDGFRAPDGFRLPMS1PMS2POLD1POLEPTENPTPN12PTPRJRAD51BRAD51CRAD51DRAD54BRAD54LRETRNF43SMAD4 (MADH4)SOX9SRCSTK11 (LKB1)TCF7L2TGFBR2TP53 (p53)
Metastatic Colorectal Cancers
AKT1ATMBRAFERBB2 (HER-2, NEU)KRASMETNRASPIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes
EPCAMMLH1MSH2MSH6PMS2
Other Colorectal Cancer Genes
DPYDERCC1TYMSUGT1A1
Lung Cancers
Adenocarcinomas
ABL1AKT1ALKATMBRAFCCND1CD274 (PD-L1)CD274 (PD-L1)CDK4CDKN2A (P16INK4A)CTNNB1DDR2EGFR (ERBB1)ERBB2 (HER-2, NEU)FGFR1FGFR3HRASKRASMAP2K1MAP3K8METMYCMYCNNRASNTRK1PIK3CA (p110-alpha)PPP2R1BPRKNPTENRETROS1SLC22A18STK11 (LKB1)TP53 (p53)TSC2
Malignant Pleural Mesotheliomas
BAP1NF2
Non-Small Cell Lung Cancers (NSCLC)
AKT1ALKATMBARD1BRAFBRCA1BRCA2BRIP1CCND1CDK12CDK4CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCLFGFR3HRASIDH1IRF1KIT (CD117)KRASMAP2K1METMLH1MLH3MSH2MSH3MSH6MYCNRASPALB2PDGFRAPIK3CA (p110-alpha)PMS1PMS2PTENRAD51BRAD51CRAD51DRAD54LRETROS1TP53 (p53)
Small Cell Lung Cancers (SCLC)
CD274 (PD-L1)CD274 (PD-L1)HRASMYCMYCNNTRK1PIK3CA (p110-alpha)PPP2R1BPTENRB1TP53 (p53)
Squamous Cell Carcinomas
BRAFCD274 (PD-L1)CD274 (PD-L1)CDKN2A (P16INK4A)DDR2EGFR (ERBB1)FGFR1FGFR3HRASMAP3K8MYCMYCNNTRK1PIK3CA (p110-alpha)PPP2R1BPTENSLC22A18TP53 (p53)TSC2
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)
ABL1ABL2 (ARG)BIRC3 (c-IAP2)BRAFBTKCDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)CRLF2 (TSLPR)EBF1EP300ETV6FBXW7FLT3GATA3HRASIKZF1IL7RJAK1JAK2JAK3KDM6AKMT2AKRASMYCNOTCH1NRASPAX5PDGFRBPLCG2PTENPTPN11RUNX1 (AML1)SF3B1SH2B3TP53 (p53)
Acute Myeloid Leukemia (AML)
ANKRD26ASXL1ATRXBRCA1BRCA2CBFBCBLBCBLCCCND2CDC25CCEBPACUX1DCKDDX41DHX15DNMT3AELANEETV6FLT3GATA1GATA2GNASHRASIDH1IDH2IKZF1IKZF2IKZF3JAK2KDM6AKIT (CD117)KMT2AKRASLUC7L2MTORNPM1NRASNUP214PDGFRAPICALMPRPF8PTPN11RB1RBBP6RPS14RUNX1 (AML1)SF3B1SLC29A1SMC1ATERTTET1TET2TP53 (p53)U2AF1U2AF2WT1ZEB2
Acute Promyelocytic Leukemia (APML; APL)
CEBPANPM1NUMA1RARARUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1CBLCEBPAEZH2FLT3JAK2KRASNPM1NRASRUNX1 (AML1)SETBP1SRSF2TET2U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRXBCL2BIRC3 (c-IAP2)BRAFCBLBCCND2CD38CUX1GNASGNB1LUC7L2MYD88NOTCH1NRASPTPN11SF3B1TP53 (p53)U2AF2XPO1ZAP70
Chronic Myeloid Leukemia (CML)
ABL1ASXL1BCORBCRBRAFCBLCREBBP (CBP)DNMT3ADNMT3BEZH2IDH1IDH2IKZF1JAK2KRASNPM1NRASRUNX1 (AML1)TET1TET2TP53 (p53)WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1BCORBCORL1CBLCEBPADNMT3AEZH2FLT3IDH1IDH2JAK2KIT (CD117)KRASMPLNF1NPM1NRASPHF6PTPN11RUNX1 (AML1)SETBP1SF3B1SRSF2STAG2TET2TP53 (p53)U2AF1ZRSR2
Hairy Cell Leukemia
BRAFCDKN1B (P27KIP1)MAP2K1TP53 (p53)
Juvenile Myelomonocytic Leukemia
ARHGAP26CBLKRASNRASPTPN11
Acute Lymphocytic Lymphomas
BIRC3 (c-IAP2)BTKCDKN2A (P16INK4A)CDKN2B (p15INK4b)MYCNOTCH1PLCG2SF3B1TP53 (p53)
B Cell Lymphomas
BCL6BRAFCD79ACHEK2 (RAD53)EZH2MAP2K1MYD88STAT6TNFRSF14TP53 (p53)
Burkitt Lymphomas
CBLBGNA13H1-4MTORMYC
Diffuse Large B Cell Lymphomas
B2MBCL2CBLBGNA13H1-4KMT2DMTORPIM1PRPF8SOCS1TNFAIP3
Follicular Lymphomas
ARID1ABCL10BCL2CARD11CREBBP (CBP)EP300EZH2FOXO1KMT2DMEF2B
Mantle Cell Lymphomas
ATMCCND1
Marginal Zone Lymphomas
KLF2MYD88NOTCH2TNFAIP3TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL10TNFAIP3
Non-Hodgkin Lymphomas
BRAFCASP10 (MCH4)NRASPIK3CA (p110-alpha)RAD54BRAD54LTP53 (p53)
Primary Cutaneous Lymphomas
CD79BMYD88
Small Lymphocytic Lymphomas
ATRXBCL2CBLBCCND2CUX1GNASLUC7L2U2AF2XPO1
T Cell Lymphomas
ARID1BATMCBLBCCR4DNMT3AIDH1IDH2INO80JAK1JAK3RHOASETD2STAT3STAT5BTET2
Myelodysplastic Syndromes
ANKRD26ASXL1ATRXBCORBCORL1CALRCBLCEBPACSF3R (GM-CSFR)CUX1DDX41DKC1DNMT3AETNK1ETV6EZH2FLT3GATA2GNASGNB1IDH1IDH2JAK2JAK3KIT (CD117)KRASMPLNF1NPM1NRASPHF6PIGAPPM1DPTPN11RAD21RUNX1 (AML1)SAMD9SAMD9LSETBP1SF3B1SMC3SRP72SRSF2STAG2STAT3TERCTERTTET2TP53 (p53)U2AF1WT1ZRSR2
Myeloproliferative Neoplasms
ASXL1BCORCALRCBLCSF3R (GM-CSFR)DNMT3AETV6EZH2IDH1IDH2JAK2KIT (CD117)MPLNOTCH1NRASPDGFRARUNX1 (AML1)SETBP1SF3B1SH2B3SRSF2STAT3STAT5BTET2TP53 (p53)U2AF1ZRSR2
Essential Thrombocythemia
ASXL1CBLIDH2JAK2MPLSF3B1TET2TP53 (p53)
Multiple Myeloma
ATMBARD1BRAFBRCA1BRCA2BRIP1CHEK1CHEK2 (RAD53)CXCR4EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCLFGFR3IDH1IDH2KIT (CD117)KRASMETNRASPALB2PDGFRARAD51BRAD51CRAD51DRETTP53 (p53)
Plasma Cell Myeloma
HRASMTORRB1SLC29A1
Polycythemia Vera
ASXL1DNMT3AEZH2IDH1JAK2NRASTET2TP53 (p53)
Primary Myelofibrosis
ASXL1CBLDNMT3AEZH2IDH1IDH2JAK2MPLNF1NRASSETBP1SF3B1SRSF2TET2TP53 (p53)
Systemic Mastocytosis
ASXL1CBLDNMT3AETV6EZH2IDH2JAK2KIT (CD117)KRASNPM1NRASRUNX1 (AML1)SETBP1SF3B1SRSF2TET2TPSAB1U2AF1
Waldenstrom Macroglobulinemia
CXCR4MYD88
Ovarian Cancers
Endometrioid Carcinomas
CDKN2A (P16INK4A)CTNNB1FANCFPOLEPPP2R1A
Epithelial Carcinomas
ABRAXAS1ARID1AATMBARD1BRAFBRCA1BRCA2BRIP1CCNE1CDK12CHEK1CHEK2 (RAD53)ERBB2 (HER-2, NEU)ERCC1KRASMRE11NBNNF1PALB2PIK3CA (p110-alpha)PTENRAD51BRAD51CRAD51DRB1TP53 (p53)WT1
Granulosa Cell Tumors
AKT1FOXL2
Mixed Adenosquamous Carcinomas
AKT1ATRATRXBLMCCND1CCND2CCNE1CDH1 (E-Cadherin)DICER1ERBB3FANCAFANCCFANCD2FANCEFANCFFANCIFANCLFANCMFBXW7FGFR1FGFR2FGFR3KIT (CD117)MYCOPCML (OBCAM)PDGFRAPIK3R1 (p85-ALPHA)POLEPRKNRAD50RAD51RAD52RAD54LRB1RPA1SMARCA4STK11 (LKB1)
Mucinous Carcinomas
ATRXCDKN2A (P16INK4A)ERBB3PDGFRA
Serous Carcinomas
ATRATRXBLMCCND1CCND2CCNE1CDH1 (E-Cadherin)CDKN2A (P16INK4A)DICER1ERBB3FANCAFANCCFANCD2FANCEFANCFFANCGFANCIFANCLFANCMFBXW7FGFR1FGFR2FGFR3KIT (CD117)MYCPPP2R1ARAD50RAD51RAD52RAD54LRB1RPA1SMARCA4
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2
Pancreatic Cancers
Adenocarcinomas
ATMCDKN2A (P16INK4A)CFTRFANCCFANCGMLH1MSH2MSH6PALB2PALLDPMS2PRSS1SMAD4 (MADH4)SPINK1STK11 (LKB1)TP53 (p53)
Advanced Ductal Adenocarcinomas
BRAFBRCA1BRCA2ERBB2 (HER-2, NEU)KRASMDM2PIK3CA (p110-alpha)
Ductal Carcinomas
APCARID1ACDK6CTNNB1ERBB3FBXW7FGFR1GNASKDM6AKRASMETMYCNRASPIK3R3POLEPREX2PTCH1PTENRNF43ROBO2SLC29A1SOX9TCF7L2
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2
Prostate Cancers
Adenocarcinomas
ABRAXAS1APCARATRBARD1BRAFBRIP1CDK12CHEK1CHEK2 (RAD53)EPHB2ERGETV1ETV4ETV5FANCAFANCLFGFR1FOXA1GEN1HRASIDH1KDM6AKLF6KMT2DKRASMAD1L1MED12MRE11MXI1MYCNBNPIK3R1 (p85-ALPHA)PPP2R2APTENRAD51BRAD51CRAD51DRAD54LRAF1RB1SPOPTP53 (p53)ZFHX3
Advanced Prostate Cancers
AKT1ATMBRCA1BRCA2PALB2PIK3CA (p110-alpha)PTEN
Ductal Carcinomas
CTNNB1
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2