Target List
Toll-Like Receptors
CD180SIGIRRTLR1TLR2TLR3TLR4TLR5TLR6TLR7TLR8TLR9TLR10
Pathogen-Specific Responses
Bacterial Response
CCL2 (MCP-1)CD14CD180FOSHRASIL10IL12AIL1BIL6CXCL8 (IL8)IRAK1HMGB1HSPA1A (HSP70-1A)JUNLTA (TNFB)LY86 (MD-1)LY96 (MD-2)NFKBIA (IκBα, MAD3)PTGS2 (COX2)RELARIPK2TLR2TLR4TLR6TNFRSF1A (TNFR1)TICAM1 (TRIF)
Viral Response
EIF2AK2IFNB1IFNGIL12AIL6IRF3PRKRARELATBK1TLR3TLR7TLR8TNFTICAM1 (TRIF)
Fungal / Parasitic Response
CLEC4EHRASHSPA1A (HSP70-1A)CXCL8 (IL8)TLR2TIRAP
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
SARM1SIGIRRTOLLIP
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
IRF3MAP3K7 (TAK1)TAB1NR2C2 (TAK1)PELI1TBK1TICAM2 (TRAM)TLR3TLR4TRAF6TICAM1 (TRIF)
MYD88-Dependent Signaling
IRAK1IRAK2MAP3K7 (TAK1)TAB1MYD88NR2C2 (TAK1)TIRAPTLR1TLR10TLR2TLR4TLR5TLR6TLR7TLR8TLR9TRAF6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
BTKCASP8 (FLICE)CHUK (IKKα)ECSITFADDIKBKB (IKKβ)IL10IL1BIRAK1IRAK2IRF3LY96 (MD-2)MAP3K1 (MEKK1)MAP3K7 (TAK1)MAP4K4NFKB1NFKB2NFKBIA (IκBα, MAD3)NFKBIL1NFRKBPPARARELRELATNFTNFRSF1A (TNFR1)UBE2N
JNK / p38 Signaling
ELK1FOSIL1BJUNMAP2K3 (MEK3)MAP2K4 (MKK4, JNKK1)MAP3K1 (MEKK1)MAP3K7 (TAK1)MAPK8 (JNK1)MAPK8IP3TNF
JAK / STAT Signaling
CCL2 (MCP-1)CSF2 (GM-CSF)IFNGIL12AIL2IL6
Interferon Regulatory Factor (IRF) Signaling
CXCL10 (INP10)IFNA1IFNB1IFNGIRF1IRF3TBK1
Cytokine Signaling
CCL2 (MCP-1)CSF3 (GCSF)IL1AIL1BIL6IRAK1IRAK2RELASIGIRRTNFTNFRSF1A (TNFR1)
Regulation of Adaptive Immunity
CD80CD86HSPD1IFNGIL10IL12AIL1BIL2MAP3K7 (TAK1)TRAF6
Toll-Like Receptor Interacting Proteins & Adaptors
BTKCD14HMGB1HRASHSPA1A (HSP70-1A)HSPD1LY86 (MD-1)LY96 (MD-2)MAPK8IP3MYD88PELI1RIPK2SARM1TICAM1 (TRIF)TICAM2 (TRAM)TIRAPTOLLIP
Downstream Effectors of Toll-Like Receptor Signaling
CASP8 (FLICE)EIF2AK2FADDIRAK1IRAK2IRAK4MAP3K7 (TAK1)TAB1NR2C2 (TAK1)PPARAPRKRAECSITTRAF6UBE2N