Target List
mTOR Complexes
mTORC1 Complex
MLST8MTORRPTOR
mTORC2 Complex
MAPKAP1 (SIN1)MLST8MTORRICTOR
mTOR Upstream Regulators
mTORC1 Positive Regulation
AKT1AKT2AKT3HRASIGF1IKBKB (IKKβ)INSINSRIRS1MAPK1 (ERK2)MAPK3 (ERK1)PDPK1PIK3C3 (VPS34)PIK3CA (p110-alpha)PIK3CBPIK3CDPIK3CGPLD1PLD2RHEBRPS6KA1RPS6KA2RPS6KA5RRAGARRAGBRRAGCRRAGDTELO2
mTORC2 Positive Regulation
AKT1AKT2AKT3MAPK1 (ERK2)MAPK3 (ERK1)PDPK1PIK3C3 (VPS34)PIK3CA (p110-alpha)PIK3CBPIK3CDPIK3CGRHEBRPS6KA1RPS6KA2RPS6KA5
mTORC1 Negative Regulation
AKT1S1 (PRAS40)CAB39CAB39LDDIT4 (REDD1)DDIT4L (REDD2)DEPTORFKBP1A (FKBP12)FKBP8IGFBP3PRKAA1 (AMPK)PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3PTENSTK11 (LKB1)STRADBTP53 (p53)TSC1TSC2YWHAQ (14-3-3θ)
mTORC2 Negative Regulation
CAB39CAB39LDDIT4 (REDD1)DDIT4L (REDD2)DEPTORPRKAA1 (AMPK)PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3STK11 (LKB1)STRADBTSC1TSC2
mTOR Downstream Effectors
mTORC1 Positive Regulation
CHUK (IKKα)EIF4BEIF4EHIF1AIKBKB (IKKβ)RPS6RPS6KB1RPS6KB2TP53 (p53)VEGFAVEGFBVEGFC
mTORC2 Positive Regulation
AKT1CDC42GSK3BHSPA4 (HSP70)ILKMYO1CPRKCAPRKCBPRKCEPRKCGRHOARPS6KB1SGK1
mTORC1 Negative Regulation
EIF4EBP1 (4E-BP1)EIF4EBP2PPP2CAPPP2R2BPTPATP53 (p53)ULK1ULK2
Cellular Processes Regulated by mTOR Signaling
Amino Acid Response
PIK3C3 (VPS34)RRAGARRAGBRRAGCRRAGD
Angiogenesis
CHUK (IKKα)DDIT4 (REDD1)DDIT4L (REDD2)HIF1AIKBKB (IKKβ)VEGFAVEGFBVEGFC
Autophagy
PIK3C3 (VPS34)ULK1ULK2
Cytoskeletal Organization
CDC42PRKCAPRKCBPRKCEPRKCGRHOA
Growth Factor Response
HRASIGF1IGFBP3MAPK1 (ERK2)MAPK3 (ERK1)RPS6KA1RPS6KA2RPS6KA5
Energy Stress
PRKAA1 (AMPK)PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3
Insulin Signaling
AKT1AKT2AKT3INSINSRIRS1PDPK1PIK3CA (p110-alpha)PIK3CBPIK3CDPIK3CGTP53 (p53)
Lipid Metabolism
PLD1PLD2
Translation
EIF4BEIF4EEIF4EBP1 (4E-BP1)EIF4EBP2PPP2CAPPP2R2BPTPARPS6RPS6KA1RPS6KA2RPS6KA5RPS6KB1RPS6KB2