Target List
Toll-Like Receptor (TLR) Signaling
Toll-Like Receptors & Cofactors
CD14LY96 (MD-2)TLR1TLR2TLR4TLR5TLR6TLR9
MYD88-Dependent
FADDIRAK1IRAK3IRF5IRF7MAP3K7 (TAK1)MYD88TIRAPTLR1TLR2TLR4TLR5TLR6TLR9TOLLIPTRAF6
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
IRF5IRF7MAP3K7 (TAK1)RIPK1TICAM1 (TRIF)TICAM2 (TRAM)TLR4TRAF6
Other Toll-Like Receptor Signaling Genes
AKT1CASP8 (FLICE)LBPPIK3CA (p110-alpha)RAC1
NOD-Like Receptor (NLR) Signaling
NOD-Like Receptors
NAIPNLRC4 (IPAF)NLRP1NLRP3NOD1 (CARD4)NOD2
Inflammasomes
CASP1 (ICE)NAIPNLRC4 (IPAF)NLRP1NLRP3PYCARD (TMS1, ASC)
Regulation of NOD-like Receptor (NLR) Signaling
BIRC3 (c-IAP2)CARD6CARD9CASP8 (FLICE)HSP90AA1MEFVPSTPIP1RIPK2SUGT1TNFXIAP
Other Bacterial Pattern Recognition Receptors (PRRs)
APCSCRPDMBT1ZBP1
Signaling Downstream of Antibacterial Responses
NFκB Signaling
CHUK (IKKα)IKBKB (IKKβ)NFKB1NFKBIA (IκBα, MAD3)RELATNFRSF1A (TNFR1)
ERK1 / ERK2 Signaling
JUNMAP2K1MAPK1 (ERK2)MAPK3 (ERK1)
JNK / p38 Signaling
JUNMAP2K3 (MEK3)MAP2K4 (MKK4, JNKK1)MAPK14 (p38ALPHA)MAPK8 (JNK1)
Apoptosis
AKT1BIRC3 (c-IAP2)CARD6CARD9CASP1 (ICE)CASP8 (FLICE)CD14FADDIFNB1IKBKB (IKKβ)IL12AIL12BIL1BIL6IRAK1JUNMAP3K7 (TAK1)MAPK1 (ERK2)MAPK8 (JNK1)MPONFKB1NFKBIA (IκBα, MAD3)PIK3CA (p110-alpha)PYCARD (TMS1, ASC)RAC1RIPK1RIPK2TNFTNFRSF1A (TNFR1)TRAF6
Inflammatory Response
AKT1APCSCCL3 (MIP-1A)CCL5 (RANTES)CD14CRPCXCL1 (GRO1, GROa, SCYB1)CXCL2 (GRO2, GROb, SCYB2)IL1BIL6CXCL8 (IL8)LBPLY96 (MD-2)LYZMEFVMYD88NFKB1NLRC4 (IPAF)NLRP3NOD1 (CARD4)RAC1RELARIPK2SLC11A1TICAM2 (TRAM)TIRAPTLR1TLR2TLR4TLR5TLR6TLR9TNFTNFRSF1A (TNFR1)TOLLIP
Cytokines & Chemokines
CCL3 (MIP-1A)CCL5 (RANTES)CXCL1 (GRO1, GROa, SCYB1)CXCL2 (GRO2, GROb, SCYB2)IFNA1IFNB1IL12AIL12BIL18IL1BIL6CXCL8 (IL8)
Antimicrobial Peptides
BPICAMPCTSGLCN2 (NGAL)LTFLYZMPOPRTN3SLPI