Target List
Insulin Signaling
AKT3IGF1IGF1RIKBKB (IKKβ)INSRIRS1IRS2MAP2K1MAPK3 (ERK1)MAPK9 (JNK2)MTORPDE3BPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PPARGC1A (PGC-1α)PTPN1 (PTP1B)RPS6KB1SLC2A4 (GLUT4)SOCS3SREBF1
Non-Insulin Dependent Diabetes Mellitus
ADIPOQ (ACRP30)HK2IKBKB (IKKβ)INSRIRS1IRS2MAPK3 (ERK1)MAPK9 (JNK2)MTORPDX1PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)SLC2A4 (GLUT4)SOCS3TNF
Adipokine Signaling
Adipokines
ADIPOQ (ACRP30)IL6LEP (Leptin)NAMPTRETNSERPINE1 (PAI-1)TNF
Receptors & Transporters
ADIPOR1ADIPOR2CD36LEPRSLC2A4 (GLUT4)TNFRSF1A (TNFR1)TNFRSF1B
Signaling Downstream of Adipokines
AKT3CHUK (IKKα)IKBKB (IKKβ)IRS1IRS2JAK2MAPK9 (JNK2)MTORNFKBIA (IκBα, MAD3)PPARAPPARGC1A (PGC-1α)RELASOCS3STAT3
Innate Immunity
CASP1 (ICE)CHUK (IKKα)IKBKB (IKKβ)IRS1IRS2NLRP3NFKBIA (IκBα, MAD3)PYCARD (TMS1, ASC)RELATLR4
Inflammation
ALOX5CASP1 (ICE)CCL2 (MCP-1)CCR4CCR5CHUK (IKKα)CXCR4IFNGIKBKB (IKKβ)IL1BIL23RIL6CXCL8 (IL8)LTA4HNLRP3OLR1PYCARD (TMS1, ASC)RELATNFTNFRSF1A (TNFR1)TNFRSF1B
Apoptosis
PPARGSERPINE1 (PAI-1)TNFCASP1 (ICE)IKBKB (IKKβ)IRS2MAPK9 (JNK2)NFKBIA (IκBα, MAD3)NLRP3PYCARD (TMS1, ASC)RELATNFRSF1A (TNFR1)JAK2PIK3CA (p110-alpha)SOCS3RPS6KB1TNFRSF1B
Metabolic Pathways
Carbohydrate Metabolism
CSHK2PCK1PDK2
Lipid Metabolism
ACACAACACBACSL1ACSL4APOECEBPACNBPFABP4FASNLEPRLIPELPLPPARAPPARGPPARGC1A (PGC-1α)SCDSREBF1SREBF2
Metabolite Transport
APOECD36FABP4RBP4SLC2A4 (GLUT4)SLC27A1UCP1VLDLR
Infiltrating Leukocyte Markers
Macrophages
CCR5CXCR4ADGRE1 (EMR1)
Th1 Cells
CCR5CD3ECXCR3IL18R1
Th2 Cells
CCR4CD3ECRLF2 (TSLPR)IL1R1
Th17 Cells
CCR6CD3EIL23R