Target List
IL6 / STAT3 Signaling
STAT3 Activators
CXCL12 (SDF1)EGFR (ERBB1)IL10IL11IL17AIL21IL23AIL6
Cell Surface Receptors
CD4CD40 (TNFRSF5)CD80CSF3R (GM-CSFR)CXCR4FASIL18R1IL1R1IL2RA (CD25)IL6RIL6ST (GP130)LIFROSMRTNFRSF10B (DR5)TNFRSF1A (TNFR1)TNFRSF1B
Signaling Upstream of IL6 / STAT3
AKT1JAK2JAK3MAP2K1MAPK1 (ERK2)MAPK14 (p38ALPHA)MAPK3 (ERK1)MAPK8 (JNK1)MTORMYCPIAS3RAC1SOCS1SOCS3SRCTYK2
Signaling Downstream of IL6 / STAT3
BAXBCL2CDC25ACDKN1A (p21CIP1, WAF1)HGFMETPIM1STAT3
IL6 / STAT3 Signaling Target Genes
CCL2 (MCP-1)CCL5 (RANTES)CD80CEBPDCXCL10 (INP10)CXCL12 (SDF1)CXCL8 (IL8)IL10IL11IL12AIL17AIL1BIL21IL6MYCSOCS3
Cytokines
CCL2 (MCP-1)CCL3 (MIP-1A)CCL4 (MIP-1B)CCL5 (RANTES)CD40LGCSF1 (MCSF)CSF2 (GM-CSF)CSF3 (GCSF)CXCL10 (INP10)CXCL12 (SDF1)CXCL8 (IL8)FASLG (TNFSF6)IL10IL11IL13IL15IL17AIL18IL1AIL1BIL2IL21IL22IL23AIL3IL4IL5IL6IL7IL9LIFLTA (TNFB)OSMTNFTNFSF10 (TRAIL)TNFSF11 (RANKL)
NFκB Signaling
IKBKB (IKKβ)NFKB1NFKBIA (IκBα, MAD3)RELATLR4