Target List
Toll-Like Receptors
Cd180 (Ly78)Tlr1Tlr2Tlr3Tlr4Tlr5Tlr6Tlr7Tlr9
Pathogen-Specific Responses
Bacterial Response
Ccl2 (Mcp-1)Cd14FosHmgb1 (QuantiNova Symbol: AABR07035218.1)HrasHspa1a (Hsp70-1)Il10Il12aIl1bIl6Irak1JunLta (Tnfb)Ly86 (MD-1)Nfkbia (Iκbα, Mad3)Pglyrp1Ptgs2 (Cox2)RelaRipk2Rnf138 (QuantiNova Symbol: AABR07031480.1)Tlr2Tlr4Tlr6Tnfrsf1a (Tnfr1)
Viral Response
Eif2ak2Ifnb1IfngIl12aIl6Irf3LOC103694380 (Tnf)RelaRnf138 (QuantiNova Symbol: AABR07031480.1)Tbk1Tlr3Tlr7
Fungal / Parasitic Response
HrasHspa1a (Hsp70-1)Tlr2
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
Tollip
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
Irf3LOC100910771 (Map3k7)Nr2c2Peli1Rnf138 (QuantiNova Symbol: AABR07031480.1)Tbk1Ticam2 (Tram)Tlr3Tlr4Traf6
MYD88-Dependent Signaling
Irak1Irak2LOC100910771 (Map3k7)Myd88Nr2c2Tlr1Tlr2Tlr4Tlr5Tlr6Tlr7Tlr9Traf6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
BtkCasp8 (Flice)Chuk (Ikbka, Ikka)FaddIkbkb (IKK2)Il10Il1bIl1r1Irak1Irak2Irf3LOC100910771 (Map3k7)LOC100912618 (Ube2v1)LOC103694380 (Tnf)Ly86 (MD-1)Map3k1 (Mekk1)Map4k4Nfkb1Nfkb2Nfkbia (Iκbα, Mad3)Nfkbib (Trip9)Nfkbil1NfrkbPparaRelRelaTnfrsf1a (Tnfr1)Tnip2TraddUbe2n
JNK / p38 Signaling
FosIl1bJunKcnh8LOC100910771 (Map3k7)LOC103694380 (Tnf)Map2k3 (Mek3)Map2k4 (Mkk4, Jnkk1)Map3k1 (Mekk1)Mapk8 (Jnk1)Mapk8ip3 (JIP3)Mapk9 (Jnk2)
JAK / STAT Signaling
Ccl2 (Mcp-1)Csf2 (Gm-csf)Csf2 (Gm-csf)Csf2 (Gm-csf)IfngIl12aIl2Il6
Interferon Regulatory Factor (IRF) Signaling
Cxcl10 (Inp10)Ifna5Ifnb1IfngIrf1Irf3Tbk1
Cytokine Signaling
Ccl2 (Mcp-1)CebpbClec4eCsf3 (Gcsf)Il1aIl1bIl1r1Il6Il6rIrak1Irak2LOC103694380 (Tnf)RelaTnfrsf1a (Tnfr1)
Regulation of Adaptive Immunity
Cd80Cd86Hspd1IfngIl10Il12aIl1bIl2LOC100910771 (Map3k7)Traf6
Toll-Like Receptor Interacting Proteins & Adaptors
BtkCd14Hmgb1 (QuantiNova Symbol: AABR07035218.1)HrasHspa1a (Hsp70-1)Hspd1Ly86 (MD-1)MalMapk8ip3 (JIP3)Myd88Peli1Pglyrp1Ripk2Rnf138 (QuantiNova Symbol: AABR07031480.1)Sarm1Ticam2 (Tram)Tollip
Downstream Effectors of Toll-Like Receptor Signaling
Casp8 (Flice)Eif2ak2FaddIrak1Irak2LOC100910771 (Map3k7)LOC100912618 (Ube2v1)Nr2c2PparaTraf6Ube2n