Target List
TGFβ Superfamily Ligands
Activins
InhaInhbaInhbb
Bone Morphogenetic Proteins
AmhBmp1Bmp2Bmp3Bmp4Bmp5Bmp6Bmp7Gdf3 (Vgr-2)Gdf5 (Cdmp-1)Gdf6Gdf7
Nodal
Nodal
TGFβ Family Members
Tgfb1Tgfb2Tgfb3
Inhibitors & Cofactors of TGFβ Signaling
BambiChrdDcnFstLtbp1Ltbp2NogTdgf1TgfbiTgfbrap1Tgif1Thbs1 (TSP-1, Tsp1)
TGFβ Superfamily Receptors
Activin Receptors
Acvr1 (Alk2)Acvr2aAcvrl1 (Alk1)
Bone Morphogenetic Protein Receptors
Amhr2Bmpr1a (Alk3)Bmpr1b (Alk6)Bmpr2
TGFβ Receptors
Tgfbr1 (Alk5)Tgfbr2Tgfbr3
Transcription Factors & Regulators
Dlx2FosGscHipk2Id1JunJunbMycRunx1 (Aml1)Smad1Smad2Smad3Smad4Smad5Smad6Smad7Sox4 (QuantiNova Symbol: AABR07027575.1)Stat1Tgfb1i1Tsc22d1
SMAD Target Genes
TGFβ / Activin-Responsive
Atf4Cdkn1a (Cip1, Waf1)Cdkn1b (P27KIP1)Cdkn2b (p15)Col1a1Col1a2DcnEmp1FosGadd45bGscHerpud1Ifrd1Igf1Igfbp3Il6JunJunbMycPdgfbPlat (tPA)Serpine1 (Pai-1)Tgfb1i1TgfbiTgif1Tnfsf10 (Trail)Tsc22d1
Bone Morphogenetic Protein Responsive
BglapDlx2Id1Id2JunbSox4 (QuantiNova Symbol: AABR07027575.1)Stat1
Molecules Regulating TGFβ Superfamily Signaling
BambiBmperCdkn2b (p15)ChrdEng (Evi-1)FstHipk2MecomNogPlau (UPAM)Runx1 (Aml1)
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Cell Adhesion Molecules
BglapEng (Evi-1)Tgfb1i1Tgfbi
Extracellular Matrix (ECM) Structural Constituents
BglapCol1a1Col1a2Ltbp1Ltbp2Plat (tPA)Tgfbi
Cellular & Developmental Processes
Apoptosis
Cdkn1a (Cip1, Waf1)Cdkn1b (P27KIP1)Igfbp3InhaInhbaStat1Tgfb1
Embryonic Development
Bmp4InhbaMecomSmad3Tdgf1
Muscle Development
DcnIgf1Smad3
Neurogenesis
Dlx2InhaInhbaNog
Reproduction
AmhAmhr2FstInhaInhbaInhbb
Skeletal Development
BglapBmp1Bmp2Bmp3Bmp4Bmp5Bmp6Bmp7Bmpr2ChrdCol1a1Col1a2Igf1InhaInhbaNog