Target List
JAK & STAT Proteins
Janus Kinase Activity
Jak1Jak2Jak3Tyk2
STAT Family Members
Stat1Stat2Stat3Stat5aStat5bStat6
JAK / STAT Signaling Regulators
Pias1Pias2PrlPtpn1 (Ptp)Ptprc (Cd45)SirpaSocs1Socs2Socs3Socs4Socs5
Receptors Binding & Activating JAK Proteins
Csf1rCxcl9EgfrEporFasFcgr1aGhrIfnar1Ifngr1Il10raIl10rbIl2ra (Cd25)Il2rgIl4rIl6st (Gp130)InsrMpl (Tpor)Nr3c1 (QuantiNova Symbol: AABR07031756.1)PdgfraPrlrPtprc (Cd45)
SH3 / SH2 Adaptor Protein Activity
CrkGrb2Sh2b1SrcStam
STAT-Interacting Transcription Factors & Regulators
Transcriptional Factors
CebpbGata3Hnf4aIrf1JunJunbMycNfkb1Nr3c1 (QuantiNova Symbol: AABR07031756.1)Smad1Smad2Smad3Smad4Smad5Sp1Usf1
Transcriptional Regulation
Yy1
STAT-Induced
STAT1-Induced
Cxcl9Irf1Nos2 (Nos2a, iNos)
STAT3-Induced
Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Ccnd1Cdkn1a (Cip1, Waf1)CebpdCrpFasIrf1JunbLOC100911545 (A2m)Lrg1MycSocs1Socs3
STAT4-Induced
Fcgr1aIfngIrf1Myc
STAT5-Induced
Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Ccnd1Cdkn1a (Cip1, Waf1)Il2ra (Cd25)Irf1Osm
STAT6-Induced
Fcer2Gata3Il4Il4r
STAT1 / STAT2 / p48 Induced
Isg15
Apoptosis
Akt1Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Cdkn1a (Cip1, Waf1)CebpbFasIfngIl4Jak2MycNfkb1PrlrSpi1
Cell Growth and / or Maintenance
Cell Cycle
Ccnd1Cdkn1a (Cip1, Waf1)JunJunb
Cell Proliferation
Il2ra (Cd25)Jak2MycPtprc (Cd45)Stat6
Cell Growth
EgfrHnf4aIfngIl4OsmPdgfraSocs1Socs2Socs3Socs4Socs5
Cell Differentiation
Ccnd1CebpbGata3Hnf4aIl20Il4Jak2JunNos2 (Nos2a, iNos)PrlrPtprc (Cd45)Smad2Socs2Socs5Stat3Stat5aStat5b
Immune Response
Acute-Phase Response
CrpF2 (Thrombin)Stat3
Inflammatory Response
CebpbCxcl9IfngIl20Il2ra (Cd25)Irf1Nfkb1Nos2 (Nos2a, iNos)
Lymphocyte Activation
IfngIl4Prlr
Other Immune Response Genes
FasFcgr1aGbp4Il4rIl6st (Gp130)Irf9Isg15Oas1aOsmPtpn11Stub1