Target List
EGFR Signaling
Bcar1CblbEgfEgfrEps8Gab1Grb2HbegfNck2Nup62Rps6ka5Shc1
Platelet-Derived Growth Factor Receptor Signaling
Bcar1PdgfaPdgfbPdgfraPlat (tPA)
Intracellular Signaling
AKT Signaling
Akt1Akt2Akt3BadCasp9Chuk (Ikbka, Ikka)FaslgFoxo3Nfkb1Pten
ERK1 / ERK2 Signaling
EgfrGrb2Kcnh8Map2k1 (MEK1)Mapk1 (Erk2)Mapk3 (ERK1)Mknk1PdgfraRaf1Rps6ka5Shc1SrcStat3
IκB Kinase / NFκB Cascade
Chuk (Ikbka, Ikka)FaslgGsk3aGsk3bNup62RhoaStat1
JAK / STAT Signaling
Eps8Gab1Grb2Jak1LOC103694903 (Ppp2ca)Nup62SrcStat1Stat3Stat5a
JNK / p38 Signaling
Map2k4 (Mkk4, Jnkk1)Map3k2 (Mekk2)Mapk10 (Jnk3)Mapk8 (Jnk1)Mapk9 (Jnk2)
MAP Kinase Signaling
Dusp1Dusp6EgfEgfrLOC103694903 (Ppp2ca)Map2k1 (MEK1)Map2k7 (Jnkk2)Mapk1 (Erk2)Mapk10 (Jnk3)Mapk3 (ERK1)Mapk8 (Jnk1)Mapk9 (Jnk2)PrkcaShc1
PI3 Kinase Signaling
Pik3ca (p110-alpha)Pik3r1 (PI3KA)Pik3r2Pten
G-Protein Signaling
Grb2HrasNrasNup62Rap1aRasa1Rhoa
Other Intracellular Signaling Molecules
ArafBrafCblbCsnk2a1Csnk2bIkbkb (IKK2)Nck2Pdpk1Plcg1Rps6kb1
Cell Survival & Growth
Apoptosis
Akt1BadBcar1Bcl2BrafCasp3Casp9FaslgFoxo3Il2LOC103694903 (Ppp2ca)Lta (Tnfb)Mapk1 (Erk2)Nfkb1Nup62Pik3r2PrkcaPtenRaf1Rasa1Stat1Tp53 (p53)
Cell Cycle
Bcl2Ccnd1Dusp1Dusp6EgfrHrasKrasLOC103694903 (Ppp2ca)Mapk1 (Erk2)Mapk3 (ERK1)NrasPdgfaPdgfbPrkcaPtenRap1aShc1Stat1Tp53 (p53)
Cell Differentiation
Foxo3Il2LOC103694903 (Ppp2ca)Tp53 (p53)
Cell Growth
Bcar1Ccnd1EgfHbegfIl2LOC103694903 (Ppp2ca)PdgfaPdgfbPdgfraRasa1Shc1Tp53 (p53)
Cell Motility
Actr2Bcar1EgfrFn1HbegfMap2k1 (MEK1)Mapk8 (Jnk1)PtenStat3
Cell Proliferation
Bcar1Bcl2EgfEgfrEps8Gab1HbegfIl2Nck2Nup62PdgfaPdgfbPdgfraPtenRaf1Shc1Tp53 (p53)
Metabolism
DNA Metabolism
Atf1Atf2 (Creb2)Creb1EgfEgfrFosLOC103694903 (Ppp2ca)Nup62Tp53 (p53)
Lipid Metabolism
ArafBrafLOC103694903 (Ppp2ca)Pik3r1 (PI3KA)Plcg1PrkcaPtenRaf1Shc1
Protein Metabolism
Actr2Akt1Akt2Akt3ArafAtf1Atf2 (Creb2)BrafCblbChuk (Ikbka, Ikka)Creb1Csnk2a1Dusp1Dusp6EgfrFosGsk3aGsk3bIkbkb (IKK2)Jak1LOC103694903 (Ppp2ca)Map2k1 (MEK1)Map2k4 (Mkk4, Jnkk1)Map2k7 (Jnkk2)Map3k2 (Mekk2)Mapk1 (Erk2)Mapk10 (Jnk3)Mapk3 (ERK1)Mapk8 (Jnk1)Mapk9 (Jnk2)Mknk1PdgfraPdpk1PrkcaPtenRaf1Rps6ka5Rps6kb1Src
Other Metabolism Genes
Col1a1Eif4eFn1Mmp7Rasa1
Development
BrafCol1a1HbegfPtenRasa1Stat3
Stimulus Response
Response to Wounding
Bcar1Bcl2Fn1HbegfIl2Nck2Nfkb1PdgfbStat3
Response to Other Stimuli
Akt1Chuk (Ikbka, Ikka)Col1a1Dusp1EgfrFaslgFosKrasLOC103694903 (Ppp2ca)Lta (Tnfb)Map2k1 (MEK1)Map2k7 (Jnkk2)Mapk1 (Erk2)Mapk8 (Jnk1)Mapk9 (Jnk2)Nfatc3Rps6ka5Stat1Stat5aTp53 (p53)
Transcription Factors & Regulators
Akt1Atf1Atf2 (Creb2)CblbCreb1Egr1Eif4eFosFoxo3Ikbkb (IKK2)JunKcnh8LOC103694903 (Ppp2ca)Mknk1Nfatc3Nfkb1Nup62Rps6ka5Stat1Stat3Stat5aTp53 (p53)
Actin & Calcium Ion Homeostasis
Actr2Bcar1CblbEgfEgfrMmp7Nck2Pdpk1Plcg1PrkcaRasa1RhoaStat1Stat3Stat5a