Target List
AKT & PI3 Kinase Family Members & Their Regulators
Akt1Akt2Akt3BtkGrb10Grb2Hspb1 (Hsp27)IlkMtcp1Pdk2Pdpk1Pik3ca (p110-alpha)Pik3cgPik3r1 (PI3KA)Pik3r2PrkcaPrkcbPrkczPtenTcl1a
IGF-1 Signaling
Csnk2a1FosGrb2HrasIgf1Igf1rIrs1JunKcnh8Map2k1 (MEK1)Mapk3 (ERK1)Mapk8 (Jnk1)Ptpn11Raf1Rasa1Shc1Sos1Srf
GSK3 Inactivation & β-Catenin Accumulation
AdarAkt1ApcCcnd1Cd14Ctnnb1Eif2ak2Gja1 (Cx43)Gsk3bIrak1Myd88Nfkb1Pdk1TirapTlr4Tollip
Cytoskeleton Regulators
Cdc42Pak1PdgfraRac1RhoaWasl
PTEN-Dependent Cell Cycle Arrest & Apoptosis
Akt1Cdkn1b (P27KIP1)FaslgFoxo3Grb2IlkItgb1Mapk1 (Erk2)Mapk3 (ERK1)Pdk1Pdk2PtenPtk2 (Fak)Rbl2Shc1Sos1
BAD Phosphorylation & Anti-Apoptotic Pathways
Akt1BadGrb2HrasIgf1rIrs1Map2k1 (MEK1)Mapk1 (Erk2)Mapk3 (ERK1)Rps6ka1Shc1Sos1Ywhah
mTOR Signaling
Akt1Eif4bEif4eEif4ebp1Eif4g1Fkbp1a (Fkbp12)MtorPdk1Pdk2PtenRhebRps6kb1Tsc1Tsc2
Regulation of eIF4e & p70 S6 Kinases
Akt1Eif4eEif4ebp1Eif4g1MtorIrs1Mapk1 (Erk2)Mapk14 (p38alpha)Mapk3 (ERK1)Pabpc1Pdk1Pdk2PrkcaPtenRps6kb1
Other AKT Signaling Genes
Casp9Chuk (Ikbka, Ikka)Foxg1Nfkbia (Iκbα, Mad3)