Target List
Protease Activated Receptors (PARs)
F2r (Par1)F2rl1 (Par2)F2rl2 (Par3)F2rl3 (Par4)
Proteases Activating Protease Activated Receptors
CtsgF10F2 (Thrombin)F3F7Mmp1PlgProc
Thrombin Signaling
Thrombin & Receptors
F2 (Thrombin)F2r (Par1)F2rl1 (Par2)F2rl2 (Par3)F2rl3 (Par4)
Signaling Downstream of Thrombin
Adcy7Akt1Gnai1HrasIkbkb (IKK2)Map2k1 (MEK1)Mapk14 (p38alpha)PrkcaPrkcePtk2 (Fak)RhoaRhohRps6kb1Src
Transcription Factors
Egr1Elk1Gata2Nfkb1RelRela
Cell Adhesion Molecules
Icam1ItgadItgavItgb1Kitlg (Scf)Kitlg (Scf)RhoaRhohS1pr1SeleSelpSrcThbs1 (TSP-1, Tsp1)Vcam1
Coagulation
F10F2 (Thrombin)F2r (Par1)F2rl1 (Par2)F2rl2 (Par3)F2rl3 (Par4)F3F7Hspa5 (Grp78)Mmp1Plau (UPAM)Plaur (uPAR)PlekPlgProcProcr (Epcr)SelpSerpinb2 (Pai-2)Serpine1 (Pai-1)TfpiThbdThbs1 (TSP-1, Tsp1)
PAR-Regulated Genes
Activated Protein C Signaling
Cd55Dkk1Ets1F3HbegfIl6ItgavJunbNr4a1 (Nur77)Plaur (uPAR)Ptgs2 (Cox2)Ptpn11RelaSerpinb2 (Pai-2)Thbs1 (TSP-1, Tsp1)Tp53 (p53)Vegfa
Thrombin Signaling
Ccl12Cd55Dkk1Ets1F3HbegfHmgcrIl1bIl6JunbKdr (Vegfr3)Kitlg (Scf)Kitlg (Scf)LOC103694380 (Tnf)Mif (QuantiNova Symbol: LOC103694877)Nab2Nr4a1 (Nur77)Plaur (uPAR)Ptgs2 (Cox2)Ptpn11S1pr3 (Edg3)Serpinb2 (Pai-2)Thbs1 (TSP-1, Tsp1)Vegfa
Factor VIIa / PAR1/2 Signaling
Ccn2Cdkn1a (Cip1, Waf1)Csf2 (Gm-csf)Csf2 (Gm-csf)Csf2 (Gm-csf)Nfkb1Plau (UPAM)Serpine1 (Pai-1)
Factor VIIa / PAR2 Signaling
Ccn1Csf1 (Mcsf)Csf2 (Gm-csf)Csf2 (Gm-csf)Csf2 (Gm-csf)Cxcl3Itgb1Vegfc
TLR4 / PAR2 Signaling
Il10Il13Il4Il6LOC103694380 (Tnf)
Other PAR-Regulated Genes
Gja1 (Cx43)Mmp2SeleSelpSerpinb5 (Maspin)Tgfb1Vcam1