Target List
Estrogen Receptors
ESR1 (ERα)ESR2 (ERβ)GPER1
Estrogen Receptor Cofactors & Interacting Proteins
AHRBCAR1BRCA1CAV1CCND1EFNA5ESR1 (ERα)ESR2 (ERβ)HSP90AA1IGF1MED1MTA1NCOA1NCOA2NCOA3NCOR1NCOR2NR0B1NR0B2NRIP1PELP1PGRPHB2SAFBTFF1 (pS2)VDR
Estrogen Receptor Target Genes
Female Sex Differentiation
BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)FSTNRIP1PGRVEGFAWNT4WNT5A
Male Sex Differentiation
BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CCND1CYP19A1WNT4WNT5A
Ovulation Cycle
BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BMP4ERBB2 (HER-2, NEU)FSTNRIP1PGRTGFB3VEGFAWNT5A
Pregnancy
FOSJUNBPGRPTGS2 (COX2)SNAI1 (SNAIL)SOCS3SPP1TGFB3WNT4
Mammary Gland Development
BMP4CAV1CCND1ERBB2 (HER-2, NEU)ERBB3IGFBP5IRS1NR3C1 (GRL)PGRPTCH1TGFB3VEGFAWNT4WNT5A
Cardiovascular System Development
C3CAV1CCL2 (MCP-1)EGR3ERBB2 (HER-2, NEU)ERBB3JUNBKLK3MMP9NRP1PTCH1PTGS2 (COX2)RARASOCS3TGFATHBS1 (TSP-1)VEGFAWNT4WNT5A
Nervous System Development
APBB1BDNFCCL2 (MCP-1)CITED2CKBCYP19A1EGR3ERBB2 (HER-2, NEU)ERBB3FOSFOXA1L1CAMLGALS1NAB2NR2F6NR3C1 (GRL)NRP1PTCH1S100A6SPP1VEGFAWNT4WNT5A
Bone Development
BMP4BMP7IGF1IGFBP5JUNBMMP9NAB2PTGS2 (COX2)SNAI1 (SNAIL)SPP1TGFB3WNT4WNT5A
Growth Regulation
BMP7CCN2CCN3CCN5EBAG9ERBB2 (HER-2, NEU)IGFBP4IGFBP5NRP1PTCH1SOCS3SPP1WNT5A
Transcription Factors
EGR3FOSFOXA1JUNBMAFFMYCNCOA1NCOA3NR3C1 (GRL)NR5A2NRIP1PGRRARASNAI1 (SNAIL)XBP1
Other Estrogen Receptor Target Genes
AKAP1CTSDCYP1A1G6PDLPLLTBP1PDZK1RALATFF1 (pS2)