Target List
Induction of Apoptosis
Death Domain Receptors
CRADDFADDTNFTNFRSF10B (DR5)
DNA Damage & Repair
ABL1CIDEACIDEBTP53 (p53)TP73
Extracellular Apoptotic Signals
CFLAR (CASPER)DAPK1TNFRSF25 (DR3)
Other Pro-Apoptotic Genes
BADBAK1BAXBCL10BCL2L11BIDBIKBNIP3BNIP3LCASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP3CASP4CASP6CASP8 (FLICE)CD27 (TNFRSF7)CD70CYCSDFFADIABLOFASFASLG (TNFSF6)GADD45AHRKLTA (TNFB)NOD1 (CARD4)PYCARD (TMS1, ASC)TNFRSF10A (TRAIL-R)TNFRSF9TNFSF10 (TRAIL)TNFSF8TP53BP2TRADDTRAF3
Anti-Apoptotic
AKT1BAG1BAG3BAXBCL2BCL2A1 (BFL1)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L10BCL2L2BFARBIRC3 (c-IAP2)BIRC5BIRC6BNIP2BNIP3BNIP3LBRAFCD27 (TNFRSF7)CD40LGCFLAR (CASPER)DAPK1FASHRKIGF1RIL10MCL1NAIPNFKB1NOL3RIPK2TNFXIAP
Regulation of Apoptosis
Negative Regulation of Apoptosis
BAG1BAG3BCL10BCL2BCL2A1 (BFL1)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L10BCL2L2BFARBIRC2 (c-IAP1)BIRC3 (c-IAP2)BIRC6BNIP2BNIP3BNIP3LBRAFCASP3CD27 (TNFRSF7)CD40LGCFLAR (CASPER)CIDEADAPK1DFFAFASIGF1RMCL1NAIPNOL3TP53 (p53)TP73XIAP
Positive Regulation of Apoptosis
ABL1AKT1BADBAK1BAXBCL2L11BIDBIKBNIP3BNIP3LCASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP4CASP6CASP8 (FLICE)CD40 (TNFRSF5)CD70CIDEBCRADDFADDFASLG (TNFSF6)HRKLTA (TNFB)LTBRNOD1 (CARD4)PYCARD (TMS1, ASC)RIPK2TNFTNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF25 (DR3)TNFRSF9TNFSF10 (TRAIL)TNFSF8TP53 (p53)TP53BP2TRADDTRAF2TRAF3
Death Domain Receptors
CRADDDAPK1FADDTNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF11B (OPG)TNFRSF1A (TNFR1)TNFRSF1BTNFRSF21TNFRSF25 (DR3)TRADD
Caspases & Regulators
Caspases
CASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP3CASP4CASP5CASP6CASP7CASP8 (FLICE)CASP9CFLAR (CASPER)CRADDPYCARD (TMS1, ASC)
Caspase Activation
AIFM1APAF1BAXBCL2L10CASP1 (ICE)CASP9NOD1 (CARD4)PYCARD (TMS1, ASC)TNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TP53 (p53)
Caspase Inhibition
CD27 (TNFRSF7)XIAP