Target List
G1 Phase & G1/S Transition
ANAPC2CCND1CCNE1CDC25ACDC34CDK4CDK6CDKN1B (P27KIP1)CDKN3CUL1CUL2CUL3E2F1SKP2
S Phase & DNA Replication
ABL1CDC6MCM2MCM3MCM4MCM5WEE1
G2 Phase & G2/M Transition
ANAPC2BCCIPBIRC5CCNA2CCNB1CCNG1CCNHCCNT1CDC25ACDK5R1CDK5RAP1CDK7CDKN3CKS1BCKS2GTSE1KPNA2MNAT1SERTAD1
M Phase
AURKBCCNB2CCNFCDC16CDC20CDC25CCDC6CDK1MRE11RAD51STMN1
Cell Cycle Checkpoint & Cell Cycle Arrest
ATMATRBRCA1BRCA2CASP3CCNA2CCNG2CDC25ACDC25CCDC34CDK1CDK2CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CDKN2B (p15INK4b)CDKN3CHEK1CHEK2 (RAD53)CUL1CUL2CUL3GADD45AHUS1KNTC1MAD2L1MAD2L2MDM2NBNRAD1RAD17RAD9ARB1RBBP8TP53 (p53)WEE1
Regulation of the Cell Cycle
ABL1ANAPC2ATRAURKABCCIPBCL2BRCA2CCNB1CCNB2CCNCCCND1CCND2CCND3CCNE1CCNFCCNHCCNT1CDC16CDC20CDC25CCDC6CDK1CDK2CDK4CDK5R1CDK6CDK7CDK8CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CKS1BE2F1E2F4GADD45AKNTC1MKI67RAD9ARB1SKP2TFDP1TFDP2WEE1
Negative Regulation of the Cell Cycle
ATMBRCA1CASP3CDKN2B (p15INK4b)RBL1RBL2TP53 (p53)