Target List
TGFβ Superfamily Ligands
Activins
INHAINHBAINHBB
Bone Morphogenetic Proteins
AMHBMP1BMP2BMP3BMP4BMP5BMP6BMP7GDF2 (BMP9)GDF3 (VGR-2)GDF5 (CDMP-1)GDF6GDF7
Nodal
NODAL
TGFβ Family Members
TGFB1TGFB2TGFB3
Inhibitors & Cofactors of TGFβ Signaling
BAMBICHRDDCNFSTLEFTY1LTBP1LTBP2NOGTGFBITGFBRAP1TGIF1THBS1 (TSP-1)
TGFβ Superfamily Receptors
Activin Receptors
ACVR1 (ALK2)ACVR2AACVRL1 (ALK1)
Bone Morphogenetic Protein Receptors
AMHR2BMPR1A (ALK3)BMPR1B (ALK6)BMPR2
TGFβ Receptors
TGFBR1 (ALK5)TGFBR2TGFBR3
Transcription Factors & Regulators
DLX2FOSGSCHIPK2ID1JUNJUNBMYCRUNX1 (AML1)SMAD1 (MADH1)SMAD2 (MADH2)SMAD3 (MADH3)SMAD4 (MADH4)SMAD5 (MADH5)SMAD7SOX4STAT1TGFB1I1TSC22D1 (TGFB1I4)
SMAD Target Genes
TGFβ / Activin-Responsive
ATF4CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2B (p15INK4b)COL1A1COL1A2DCNEMP1FOSGADD45BGSCHERPUD1IFRD1IGF1IGFBP3IL6JUNJUNBMYCPDGFBSERPINE1 (PAI-1)TGFB1I1TGFBITGIF1TNFSF10 (TRAIL)TSC22D1 (TGFB1I4)
Bone Morphogenetic Protein Responsive
BGLAPDLX2ID1ID2JUNBSOX4STAT1
Molecules Regulating TGFβ Superfamily Signaling
BAMBIBMPERCDKN2B (p15INK4b)CHRDENG (EVI-1)FSTHIPK2MECOMNOGPLAU (UPA)RUNX1 (AML1)SMURF1
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Cell Adhesion Molecules
BGLAPENG (EVI-1)TGFB1I1TGFBI
Extracellular Matrix (ECM) Structural Constituents
BGLAPCOL1A1COL1A2LTBP1LTBP2TGFBI
Cellular & Developmental Processes
Apoptosis
CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)HIPK2IGFBP3INHAINHBASTAT1TGFB1
Embryonic Development
BMP4INHBAMECOMSMAD3 (MADH3)SMURF1
Muscle Development
DCNIGF1SMAD3 (MADH3)
Neurogenesis
DLX2INHAINHBANOG
Reproduction
AMHAMHR2FSTINHAINHBAINHBB
Skeletal Development
BGLAPBMP1BMP2BMP3BMP4BMP5BMP6BMP7BMPR2CHRDCOL1A1COL1A2IGF1INHAINHBANOG