Target List
Vasodilation
ACEACE2ADMADRB1AGTR1AGTR2CALCACPS1EDNRBEPHX2GCH1KCNJ8KNG1NOS3 (eNOS)NPPBNPPCNPR1P2RX4PDE5A
Vasoconstriction
ACEACE2ADMADRA1BAGTAGTR1ALOX5AVPAVPR1ABDKRB2BMPR2CACNA1CCAV1ECE1EDN1EDN2EDNRAEDNRBNPPCNPY1RPTGS1 (COX1)PTGS2 (COX2)UTS2R
Vasotone
AGTR1DRD3NOS3 (eNOS)NPPBNPPCREN
Smooth Muscle Contraction
ACTA2 (α-SMA)ADRA1BADRB1BDKRB2CACNA1CCAV1EDN1EDN2EDNRAEDNRBKCNMA1KNG1P2RX4PTGS1 (COX1)PTGS2 (COX2)UTS2
Smooth Muscle Relaxation
GUCY1A1KCNMA1P2RX4
Myosin Light Chain Kinases
MYLKMYLK2MYLK3
Blood Pressure Regulation
ACEACE2ACTA2 (α-SMA)AGTAGTR2AVPAVPR1AAVPR1BBDKRB2CACNA1CCALCADRD3DRD5ECE1EDN1EDN2EDNRBEPHX2GCH1GUCY1A1NOS3 (eNOS)NPPBNPPCNPR1NPY1RP2RX4PTGS1 (COX1)PTGS2 (COX2)RENUTS2UTS2R
Renin-Angiotensin System
ACEACE2AGTAGTR1ECE1REN
Nitric Oxide Signaling
AGTAGTR2GUCY1A1GUCY1B1NOSIPNOSTRIN
Nitric Oxide Metabolism
AGTR2ARG2CAV1CPS1EDN1GCH1GCHFRHIF1ANOS3 (eNOS)P2RX4
Cyclic-GMP Synthesis & Signaling
ADRA1DGUCY1B1PDE3BPRKG1PRKG2PTGIRS1PR1
Osmotic Stress
AGTAVPAVPR1BBDKRB2KCNMA1
Hypoxia Signaling
ACEADMCAV1ECE1EDN1EDNRAHIF1AKCNMA1NOS3 (eNOS)NPPCPDE5A
Secondary Messenger-Mediated Signaling
ADRA1DPDE3BPTGIRS1PR1SPHK1
Ion Transport
ATP2C1ATP6AP2BDKRB1CHRNA1CHRNB1CLIC1CLIC4CLIC5CNGA1CNGA2CNGA3CNGA4CNGB1CNGB3ITPR1ITPR2PLCG2SCNN1ASCNN1BSCNN1GSLC7A1
Lipid Metabolism
PDE3APDE3BPLCG1PLCG2SPHK1SPHK2