Target List
Notch Signaling Pathway
Notch Ligands
NOTCH1NOTCH2NOTCH2NLANOTCH3NOTCH4
Notch Binding
DLL1 (DELTA1)DLL3DLL4DTX1JAG1JAG2LFNGMFNGNUMBRFNG
Notch Receptor Processing
ADAM10ADAM17 (CD156B)NCSTNPSEN1PSEN2PSENEN (PEN2)
Transcription Factors & Cofactors
EP300HDAC1MAML1MAML2NCOR2RBPJLSNW1 (SKIIP)
Notch Target Genes
Apoptosis
CDKN1A (p21CIP1, WAF1)CFLAR (CASPER)FOSL1 (FRA-1)ID1IL2RA (CD25)NFKB1PTCRA
Cell Cycle
CCND1CDKN1A (p21CIP1, WAF1)
Cell Adhesion Molecules
CD44ERBB2 (HER-2, NEU)
Cell Differentiation & Development
DTX1HES1HES5HEY1HEY2HEYLJAG1KRT1LFNGLORNOTCH1PPARG
Neurogenesis
ERBB2 (HER-2, NEU)FOSHES1HEY1NR4A2 (NURR1)
Immune Response
CHUK (IKKα)IFNGIL17BIL2RA (CD25)NFKB1NFKB2STAT6
Transcription Factors & Cofactors
FOSFOSL1 (FRA-1)HES1HES5HEY1HEY2HEYLID1NFKB1NFKB2NR4A2 (NURR1)PPARGSTAT6
Other Notch Signaling Genes
Apoptosis
AXIN1CTNNB1
Cell Cycle
AXIN1CCNE1JAG2NOTCH2VEGFD (VEGFD)
Cell Proliferation & Differentiation
FZD3LRP5PAX5SHHSTILVEGFD (VEGFD)
Neurogenesis
NEURL1 (NEU1)PAX5ZIC2 (HPE5)
Transcription Factors & Cofactors
AES (TLE5, Groucho)CBLCTNNB1GLI1HOXB4HRPAX5POFUT1RUNX1 (AML1)SUFUTLE1
Other Notch Signaling Genes
LMO2MMP7SEL1LSH2D1A
Pathways Crosstalking with Notch Signaling
Hedgehog Signaling
GLI1GSK3BSHHSMOSUFU
WNT Signaling
AES (TLE5, Groucho)AXIN1CCN4CTNNB1FZD2FZD3FZD4FZD7GSK3BLRP5TLE1WNT11