Target List
Cholestasis
ABCB1 (MDR1, PGY1)ABCB4ABCC2 (MRP2, cMOAT)ABCC3 (MRP3, MOAT-D)ATP8B1ICAM1PDYNRDXSLC51A
Steatosis
Up-Regulated in Steatosis
CD36FASNLPLSCD
Down-Regulated in Steatosis
PPARASREBF1
Phospholipidosis
Up-Regulated in Phospholipidosis
ASAH1FABP1HPNLSSMRPS18BS100A8SERPINA3WIPI1
Down-Regulated in Phospholipidosis
SLC2A3TAGLN
Regulated in Phospholipidosis
ABCB1 (MDR1, PGY1)TIMM10B
Hepatotoxicity
Up-Regulated in Hepatotoxicity
ALDOAAPEX1BTG2CASP3CCNG1CRYL1DDIT4L (REDD2)DNAJB11DNAJC3GADD45AGCLCGSRHMOX1HYOU1KRT18KRT8NQO1PLA2G12ASLC17A3TXNRD1YRDC
Down-Regulated in Hepatotoxicity
AVPR1ABHMTCA3CXCL12 (SDF1)CYP1A2FADS1FMO1HAO2IGFALSMBL2RB1THRSP
Regulated in Hepatotoxicity
ABCB11MAOBPYGLTIMM10B
Nongenotoxic Hepatocarcinogenicity
Up-Regulated in Nongenotoxic Hepatocarcinogenicity
ALDOAAPEX1BTG2CCNG1CDKN1A (p21CIP1, WAF1)DDX39AKRT18KRT8MRPS18BTXNRD1
Necrosis
Up-Regulated in Necrosis
CD68CEMIP2COL4A1IL6ST (GP130)IPO4MAP3K6NUS1OSMRPSME3SERPINE1 (PAI-1)SKILSLC39A6
Down-Regulated in Necrosis
CDC14BEMC9FAM214AL2HGDHLGR5MCM10MLXIPLRHBG
Regulated in Necrosis
CDKN1A (p21CIP1, WAF1)DDX39A