Target List
Differentially Methylated Promoters
APAF1CADM1 (TSLC1)CDH1 (E-Cadherin)CDH13CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN1C (p57Kip2)CDKN2B (p15INK4b)DAPK1DKK3DLC1EGR3HIC1JUNBMEIS1MLH1NPM1PTENSFRP2SFRP4SFRP5SOCS1TP53 (p53)WIF1
BCR-ABL Pathway
ABL1BCRGRB2JAK2SHC1STAT3STAT5ASTAT5B
JAK / STAT Signaling
AKT1CSF3 (GCSF)IFNA1IL4IL6JAK2SOCS1STAT1STAT3STAT5ASTAT5B
Hematopoiesis
BCL2CSF3 (GCSF)CTNNB1IL4JAK2LMO2PMLRUNX1 (AML1)STAT5ASTAT5BTAL1TP53 (p53)
Myeloid Cell Differentiation
CTNNB1FOXO3IL4JUNLMO2RUNX1 (AML1)SPI1STAT5ASTAT5BTAL1
Immune System Development
BCL2CSF3 (GCSF)CTNNB1IL4JAK2LMO2MLH1PMLRUNX1 (AML1)STAT5ASTAT5BTAL1TLX1TP53 (p53)
Lymphocyte Proliferation & Differentiation
BCL2CSF3 (GCSF)CTNNB1IL4IL6STAT5ASTAT5B
Cytokines & Chemokines
CCL3 (MIP-1A)CSF3 (GCSF)CXCL10 (INP10)CXCL8 (IL8)IFNA1IL10IL12AIL1R1IL4IL6
Malignancy
BAALCBMPR1B (ALK6)BTG3CCN2CD34CDC42EP3GAS2L3MN1NR4A3 (NOR1)RGS12
Leukemia Therapeutic Targets
AKT1ALOX5BCL2CTNNB1FGRFOXO3HCKHDAC1HSP90AA1IFNA1JAK2MCL1MERTKMTORPMLPRKCBRAC2SMO
Leukemia Stem Cell Transcriptional Regulators
CEBPBGATA1IKZF3JUNLMO1LMO2LYL1MEIS1NFKB1RUNX1 (AML1)RUNX2RUNX3SPI1STAT1STAT3STAT5ATAL1TLX1TLX3