Target List
Acute Rejection - Innate Immunity
Pattern Recognition Receptors (PRRs)
TLR3TLR4TLR9
Cytokines
CCL11 (Eotaxin)CCL2 (MCP-1)CCL4 (MIP-1B)CCL5 (RANTES)CSF2 (GM-CSF)CXCL10 (INP10)CXCL8 (IL8)IFNGIL10IL12AIL13IL16IL1BIL2IL2RA (CD25)IL3IL32IL4IL5IL6TNF
Other Innate Immunity Genes
ADAM17 (CD156B)C3CASP1 (ICE)CASP3CASP8 (FLICE)CCR2CCR3CD14CD28CD8AFASFASLG (TNFSF6)FCGR1AGZMAGZMBMS4A1NFKB1NOS2 (iNOS)PRF1PSMB9STAT1STAT6TAP1 (ABCB2)TNFAIP3TNFSF10 (TRAIL)
Acute Rejection - Adaptive Immunity
Th1 Markers & Immune Response
CCR5CCR7CD80CTLA4CXCR3IFNGSTAT4
Th2 Markers & Immune Response
CD86IL10IL13IL4IL5IL6
T-Cell Activation
CD80CD86ICAM1IFNG
Cytokines
CCL2 (MCP-1)CCL4 (MIP-1B)CCL5 (RANTES)CSF2 (GM-CSF)CXCL10 (INP10)IFNGIL10IL13IL4IL5IL6TNF
Leukocyte Recruitment
CD40 (TNFRSF5)CD40LGICAM1THBS1 (TSP-1)VCAM1
Chronic Rejection
Pro-Fibrotic
CCL3 (MIP-1A)CCN2IL13IL4IL5
Anti-Fibrotic
BMP7COL1A2IFNGIL10THBS2
Cell Adhesion Molecules
ICAM1ITGA2ITGAEITGAMVCAM1
Cellular Infiltration
BMP7CCR2CD44COL1A2CX3CR1CXCL11 (I-TAC, IP-9)CXCL9 (MIG)CXCR4MMP1MMP2MMP7MMP9PECAM1TGFB1TGFB2TGFB3THBS2TIMP1VEGFA