Target List
Differentially Methylated Promoters
Abcb1a (Mdr1)ApcArCav1Ccna1Cdh1 (E-cadherin)Cdkn2a (INK4A, p16, p19ARF)Dab2ipDkk3Dlc1EdnrbGpx3Gstp1Mgmt (Agt)Msx1Ptgs2 (Cox2)RarbRassf1Rbp1Sfrp1Slc5a8Timp2
Up-Regulated in Prostate Cancer
Arntl (Bmal1)Ect2Etv1HalIgfbp5LOC100910882 (Rbm39)Mto1Pdpk1Socs3Sox4 (QuantiNova Symbol: AABR07027575.1)Supt7l
Down-Regulated in Prostate Cancer
Ccnd2Cln3GcaIgf1Lgals4Loxl1NexnPpp2r1bSfrp1Slc5a8Tfpi2Usp5
Metastatic Potential
Creb1Ints6MaxNdrg3Pes1Scaf11
Androgen Receptor Signaling
ArCav1Ccnd1DaxxEgfrGnrh1Igf1Il6Nfkb1Nrip1PtenShbgTgfb1i1Timp2Timp3Vegfa
AKT & PI3 Kinase Signaling
Akt1ArBcl2Ccnd1Ccnd2Cdh1 (E-cadherin)Cdkn2a (INK4A, p16, p19ARF)Dab2ipEgfrGnrh1Igf1Il6Mapk1 (Erk2)Nfkb1Pdpk1PtenTimp2Timp3Tp53 (p53)Vegfa
PTEN Signaling
Akt1EgfrGnrh1Igf1Il6Mapk1 (Erk2)Pdpk1PtenTimp2Timp3Tp53 (p53)Vegfa
Apoptosis
Bcl2Casp3Cdkn1a (Cip1, Waf1)Cdkn2a (INK4A, p16, p19ARF)EgfrEtv1Gnrh1Igf1Il6Mapk1 (Erk2)Nfkb1PtenTimp2Timp3Tp53 (p53)Vegfa
Cell Cycle
ApcBcl2Casp3Cav2Ccna1Ccnd1Ccnd2Cdkn1a (Cip1, Waf1)Cdkn2a (INK4A, p16, p19ARF)Dab2ipEgfrGadd45aIgf1Ppp2r1bPtenPtgs2 (Cox2)Rb1Sfn (14-3-3σ)Tp53 (p53)
Transcription Factors
ArArntl (Bmal1)Cdkn2a (INK4A, p16, p19ARF)Creb1DaxxEgr3ErgEtv1LOC100910882 (Rbm39)MaxMsx1Nfkb1Nkx3-1Nrip1RarbSox4 (QuantiNova Symbol: AABR07027575.1)Srebf1Supt7lTp53 (p53)
Fatty Acid Metabolism
AcacaCamkk1FasnHmgcrIgf1Prkab1Srebf1Stk11 (Lkb1)
Other Prostate Cancer Genes
Mki67Ptgs1 (Cox1)Tmprss2